Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53

J Med Chem. 2000 Aug 24;43(17):3205-8. doi: 10.1021/jm990966p.
No abstract available

MeSH terms

  • Amino Acid Substitution
  • Crystallography, X-Ray
  • Humans
  • Ligands
  • Models, Molecular
  • Nuclear Proteins*
  • Peptide Fragments / chemistry
  • Peptides / chemical synthesis
  • Peptides / chemistry*
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / chemistry*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-mdm2
  • Structure-Activity Relationship
  • Tumor Suppressor Protein p53 / antagonists & inhibitors
  • Tumor Suppressor Protein p53 / chemistry*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Ligands
  • Nuclear Proteins
  • Peptide Fragments
  • Peptides
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2