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Steroidal cardiac Na+/K+ ATPase inhibitors exhibit strong anti-cancer potential in vitro and in prostate and lung cancer xenografts in vivo.
Dimas K, Papadopoulou N, Baskakis C, Prousis KC, Tsakos M, Alkahtani S, Honisch S, Lang F, Calogeropoulou T, Alevizopoulos K, Stournaras C. Dimas K, et al. Among authors: calogeropoulou t. Anticancer Agents Med Chem. 2014 Jun;14(5):762-70. doi: 10.2174/18715206113136660338. Anticancer Agents Med Chem. 2014. PMID: 24066843
A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells.
Honisch S, Alkahtani S, Kounenidakis M, Liu G, Alarifi S, Al-Yahya H, Dimas K, AlKahtane AA, Prousis KC, Al-Dahmash B, Calogeropoulou T, Alevizopoulos K, Lang F, Stournaras C. Honisch S, et al. Among authors: calogeropoulou t. Anticancer Agents Med Chem. 2014;14(8):1161-8. doi: 10.2174/1871520614666140618114418. Anticancer Agents Med Chem. 2014. PMID: 24942548
Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen receptor.
Alevizopoulos K, Dimas K, Papadopoulou N, Schmidt EM, Tsapara A, Alkahtani S, Honisch S, Prousis KC, Alarifi S, Calogeropoulou T, Lang F, Stournaras C. Alevizopoulos K, et al. Among authors: calogeropoulou t. Oncotarget. 2016 Apr 26;7(17):24415-28. doi: 10.18632/oncotarget.8329. Oncotarget. 2016. PMID: 27027435 Free PMC article.
Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.
Benítez D, Medeiros A, Fiestas L, Panozzo-Zenere EA, Maiwald F, Prousis KC, Roussaki M, Calogeropoulou T, Detsi A, Jaeger T, Šarlauskas J, Peterlin Mašič L, Kunick C, Labadie GR, Flohé L, Comini MA. Benítez D, et al. Among authors: calogeropoulou t. PLoS Negl Trop Dis. 2016 Apr 12;10(4):e0004617. doi: 10.1371/journal.pntd.0004617. eCollection 2016 Apr. PLoS Negl Trop Dis. 2016. PMID: 27070550 Free PMC article.
Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.
Pediaditakis I, Efstathopoulos P, Prousis KC, Zervou M, Arévalo JC, Alexaki VI, Nikoletopoulou V, Karagianni E, Potamitis C, Tavernarakis N, Chavakis T, Margioris AN, Venihaki M, Calogeropoulou T, Charalampopoulos I, Gravanis A. Pediaditakis I, et al. Among authors: calogeropoulou t. Neuropharmacology. 2016 Dec;111:266-282. doi: 10.1016/j.neuropharm.2016.09.007. Epub 2016 Sep 9. Neuropharmacology. 2016. PMID: 27618740
68 results