FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction

Kyriakos C Prousis; Nicolaos Avlonitis; Georgios A Heropoulos; Theodora Calogeropoulou

doi:10.1016/j.ultsonch.2013.10.018

FeCl3-catalysed ultrasonic-assisted, solvent-free synthesis of 4-substituted coumarins. A useful complement to the Pechmann reaction

Ultrason Sonochem. 2014 May;21(3):937-42. doi: 10.1016/j.ultsonch.2013.10.018. Epub 2013 Oct 29.

Authors

Kyriakos C Prousis¹, Nicolaos Avlonitis¹, Georgios A Heropoulos¹, Theodora Calogeropoulou²

Affiliations

¹ Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece.
² Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece. Electronic address: tcalog@eie.gr.

PMID: 24262761
DOI: 10.1016/j.ultsonch.2013.10.018

Abstract

The catalytic activity of FeCl3 for the synthesis of a variety of 4-substituted coumarins using high energy techniques has been investigated. The ultrasonic-assisted conditions provide a useful complement to the Pechmann reaction, affording the coumarin derivatives in excellent yields, under solvent-free conditions, in short reaction times using an inexpensive, mild and benign Lewis acid catalyst.

Keywords: FeCl(3) catalyst; Microwave; Pechmann reaction; Solvent-free; Ultrasound.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Chemistry Techniques, Synthetic / methods*
Chlorides / chemistry*
Coumarins / chemical synthesis*
Coumarins / chemistry*
Ferric Compounds / chemistry*
Green Chemistry Technology
Ultrasonics*

Substances

Chlorides
Coumarins
Ferric Compounds
coumarin
ferric chloride