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Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma.
Gelli E, Soncini D, Becherini P, Martinuzzi C, Todoerti K, Cagnetta A, Aquino S, Guolo F, Miglino M, Bruzzone S, Nencioni A, Neri A, Lemoli RM, Cea M. Gelli E, et al. Among authors: bruzzone s. Blood Adv. 2023 Jul 25;7(14):3472-3478. doi: 10.1182/bloodadvances.2022009035. Blood Adv. 2023. PMID: 36897214 Free PMC article. No abstract available.
APO866 activity in hematologic malignancies: a preclinical in vitro study.
Cea M, Zoppoli G, Bruzzone S, Fruscione F, Moran E, Garuti A, Rocco I, Cirmena G, Casciaro S, Olcese F, Pierri I, Cagnetta A, Ferrando F, Ghio R, Gobbi M, Ballestrero A, Patrone F, Nencioni A. Cea M, et al. Among authors: bruzzone s. Blood. 2009 Jun 4;113(23):6035-7; author reply 6037-8. doi: 10.1182/blood-2009-03-209213. Blood. 2009. PMID: 19498032 Free article. No abstract available.
Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.
Bruzzone S, Fruscione F, Morando S, Ferrando T, Poggi A, Garuti A, D'Urso A, Selmo M, Benvenuto F, Cea M, Zoppoli G, Moran E, Soncini D, Ballestrero A, Sordat B, Patrone F, Mostoslavsky R, Uccelli A, Nencioni A. Bruzzone S, et al. PLoS One. 2009 Nov 19;4(11):e7897. doi: 10.1371/journal.pone.0007897. PLoS One. 2009. PMID: 19936064 Free PMC article.
Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.
Zoppoli G, Cea M, Soncini D, Fruscione F, Rudner J, Moran E, Caffa I, Bedognetti D, Motta G, Ghio R, Ferrando F, Ballestrero A, Parodi S, Belka C, Patrone F, Bruzzone S, Nencioni A. Zoppoli G, et al. Among authors: bruzzone s. Exp Hematol. 2010 Nov;38(11):979-88. doi: 10.1016/j.exphem.2010.07.013. Epub 2010 Aug 7. Exp Hematol. 2010. PMID: 20696207 Free article.
Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.
Cea M, Soncini D, Fruscione F, Raffaghello L, Garuti A, Emionite L, Moran E, Magnone M, Zoppoli G, Reverberi D, Caffa I, Salis A, Cagnetta A, Bergamaschi M, Casciaro S, Pierri I, Damonte G, Ansaldi F, Gobbi M, Pistoia V, Ballestrero A, Patrone F, Bruzzone S, Nencioni A. Cea M, et al. Among authors: bruzzone s. PLoS One. 2011;6(7):e22739. doi: 10.1371/journal.pone.0022739. Epub 2011 Jul 27. PLoS One. 2011. PMID: 21818379 Free PMC article.
NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.
Magnone M, Bauer I, Poggi A, Mannino E, Sturla L, Brini M, Zocchi E, De Flora A, Nencioni A, Bruzzone S. Magnone M, et al. Among authors: bruzzone s. J Biol Chem. 2012 Jun 15;287(25):21067-81. doi: 10.1074/jbc.M111.324269. Epub 2012 Apr 30. J Biol Chem. 2012. PMID: 22547068 Free PMC article.
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Bauer I, Grozio A, Lasigliè D, Basile G, Sturla L, Magnone M, Sociali G, Soncini D, Caffa I, Poggi A, Zoppoli G, Cea M, Feldmann G, Mostoslavsky R, Ballestrero A, Patrone F, Bruzzone S, Nencioni A. Bauer I, et al. Among authors: bruzzone s. J Biol Chem. 2012 Nov 30;287(49):40924-37. doi: 10.1074/jbc.M112.405837. Epub 2012 Oct 18. J Biol Chem. 2012. PMID: 23086953 Free PMC article.
200 results