Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma

Blood Adv. 2023 Jul 25;7(14):3472-3478. doi: 10.1182/bloodadvances.2022009035.

Elisa Gelli¹, Debora Soncini¹, Pamela Becherini^{1

2}, Claudia Martinuzzi², Katia Todoerti³, Antonia Cagnetta^{1

2}, Sara Aquino⁴, Fabio Guolo^{1

2}, Maurizio Miglino^{1

2}, Santina Bruzzone⁵, Alessio Nencioni⁶, Antonino Neri⁷, Roberto M Lemoli^{1

2}, Michele Cea^{1

2}

¹ Clinic of Hematology, Department of Internal Medicine, University of Genoa, Genoa, Italy.
² IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
³ Department of Hematology, Fondazione Cà Granda IRCCS Policlinico, Milan, Italy.
⁴ Division of Hematology and Hematopoietic Stem Cell Transplantation Unit, Ospedale Policlinico San Martino, Genoa, Italy.
⁵ Department of Experimental Medicine, University of Genova, Genova, Italy.
⁶ Department of Internal Medicine, University of Genoa, Genoa, Italy.
⁷ Scientific Directorate, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

No abstract available

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