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Tumor immune evasion arises through loss of TNF sensitivity.
Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J. Kearney CJ, et al. Among authors: brown kk. Sci Immunol. 2018 May 18;3(23):eaar3451. doi: 10.1126/sciimmunol.aar3451. Sci Immunol. 2018. PMID: 29776993
Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia.
Bjelosevic S, Gruber E, Newbold A, Shembrey C, Devlin JR, Hogg SJ, Kats L, Todorovski I, Fan Z, Abrehart TC, Pomilio G, Wei A, Gregory GP, Vervoort SJ, Brown KK, Johnstone RW. Bjelosevic S, et al. Among authors: brown kk. Cancer Discov. 2021 Jun;11(6):1582-1599. doi: 10.1158/2159-8290.CD-20-0738. Epub 2021 Jan 12. Cancer Discov. 2021. PMID: 33436370
Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death.
Garciaz S, Guirguis AA, Müller S, Brown FC, Chan YC, Motazedian A, Rowe CL, Kuzich JA, Chan KL, Tran K, Smith L, MacPherson L, Liddicoat B, Lam EYN, Cañeque T, Burr ML, Litalien V, Pomilio G, Poplineau M, Duprez E, Dawson SJ, Ramm G, Cox AG, Brown KK, Huang DCS, Wei AH, McArthur K, Rodriguez R, Dawson MA. Garciaz S, et al. Among authors: brown fc, brown kk. Cancer Discov. 2022 Mar 1;12(3):774-791. doi: 10.1158/2159-8290.CD-21-0522. Cancer Discov. 2022. PMID: 34862195 Free PMC article.
The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis.
Ong AJS, Bladen CE, Tigani TA, Karamalakis AP, Evason KJ, Brown KK, Cox AG. Ong AJS, et al. Among authors: brown kk. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2217425120. doi: 10.1073/pnas.2217425120. Epub 2023 May 22. Proc Natl Acad Sci U S A. 2023. PMID: 37216554 Free PMC article.
448 results