AMPK CA(R)Sts a new light on amino acid sensing

Kristin K Brown

doi:10.15252/embj.2021109575

AMPK CA(R)Sts a new light on amino acid sensing

EMBO J. 2021 Nov 2;40(21):e109575. doi: 10.15252/embj.2021109575. Epub 2021 Sep 28.

Author

Kristin K Brown^{1

2

3}

Affiliations

¹ Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
² The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic., Australia.
³ Department of Biochemistry and Pharmacology, The University of Melbourne, Melbourne, Vic., Australia.

Abstract

AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. However, its ability to sense alterations in amino acid levels is poorly understood. Recent work by Yuan et al (2021) identifies a novel mechanism of AMPK regulation responsive to changes in availability of the sulfur-containing amino acid cysteine.

Publication types

Comment

MeSH terms

AMP-Activated Protein Kinases* / genetics
AMP-Activated Protein Kinases* / metabolism
Amino Acids*
Energy Metabolism
Fatty Acids
Glucose

Substances

Amino Acids
Fatty Acids
AMP-Activated Protein Kinases
Glucose