Brophy DF - Search Results

1

Factor VIIa treatment increases circulating extracellular vesicles in hemophilia patients: Implications for the therapeutic hemostatic effect of FVIIa.

Das K, Pendurthi UR, Manco-Johnson M, Martin EJ, Brophy DF, Rao LVM. Das K, et al. Among authors: brophy df. J Thromb Haemost. 2022 Aug;20(8):1928-1933. doi: 10.1111/jth.15768. Epub 2022 Jun 6. J Thromb Haemost. 2022. PMID: 35608928 Free PMC article. No abstract available.

2

Factor VIIa analog has marked effects on platelet function and clot kinetics in blood from patients with hemophilia A.

Brophy DF, Martin EJ, Nolte ME, Kuhn JG, Barrett JC, Ezban M. Brophy DF, et al. Blood Coagul Fibrinolysis. 2010 Sep;21(6):539-46. doi: 10.1097/MBC.0b013e32833b63e9. Blood Coagul Fibrinolysis. 2010. PMID: 20581663

3

Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets.

Enoksson M, Martin EJ, Holmberg H, Jensen MS, Kjelgaard-Hansen M, Egebjerg T, Buchardt J, Krogh TN, Demuth H, Sanfridson A, Hilden I, Kjalke M, Brophy DF. Enoksson M, et al. Among authors: brophy df. J Thromb Haemost. 2020 Jan;18(1):104-113. doi: 10.1111/jth.14644. Epub 2019 Oct 14. J Thromb Haemost. 2020. PMID: 31549480 Free article.

4

Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays.

Brophy DF, Martin EJ, Barrett JC, Nolte ME, Kuhn JG, Hedner U, Ezban M. Brophy DF, et al. Blood Coagul Fibrinolysis. 2011 Sep;22(6):541-6. doi: 10.1097/MBC.0b013e328348d9e5. Blood Coagul Fibrinolysis. 2011. PMID: 21681082

5

Platelets retain inducible alpha granule secretion by P-selectin expression but exhibit mechanical dysfunction during trauma-induced coagulopathy.

St John AE, Newton JC, Martin EJ, Mohammed BM, Contaifer D Jr, Saunders JL, Brophy GM, Spiess BD, Ward KR, Brophy DF, López JA, White NJ. St John AE, et al. Among authors: brophy gm, brophy df. J Thromb Haemost. 2019 May;17(5):771-781. doi: 10.1111/jth.14414. Epub 2019 Mar 18. J Thromb Haemost. 2019. PMID: 30784176 Free PMC article.

6

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment.

Cudjoe EK Jr, Hassan ZH, Kang L, Reynolds PS, Fisher BJ, McCarter J, Sweeney C, Martin EJ, Middleton P, Ellenberg M, Fowler AA 3rd, Spiess BD, Brophy DF, Hawkridge AM, Natarajan R. Cudjoe EK Jr, et al. Among authors: brophy df. J Thromb Haemost. 2019 Nov;17(11):1827-1837. doi: 10.1111/jth.14580. Epub 2019 Aug 25. J Thromb Haemost. 2019. PMID: 31322812 Free article.

7

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.

Al-Horani RA, Abdelfadiel EI, Afosah DK, Morla S, Sistla JC, Mohammed B, Martin EJ, Sakagami M, Brophy DF, Desai UR. Al-Horani RA, et al. Among authors: brophy df. J Thromb Haemost. 2019 Dec;17(12):2110-2122. doi: 10.1111/jth.14606. Epub 2019 Sep 10. J Thromb Haemost. 2019. PMID: 31397071 Free PMC article.

8

Antifactor Xa activity correlates to thrombin generation time, platelet contractile force and clot elastic modulus following ex vivo enoxaparin exposure in patients with and without renal dysfunction.

Brophy DF, Martin EJ, Best AM, Gehr TW, Carr ME. Brophy DF, et al. J Thromb Haemost. 2004 Aug;2(8):1299-304. doi: 10.1111/j.1538-7836.2004.00789.x. J Thromb Haemost. 2004. PMID: 15304034 Free article.

9

Thrombin generation time is a novel parameter for monitoring enoxaparin therapy in patients with end-stage renal disease.

Brophy DF, Martin EJ, Gehr TW, Best AM, Paul K, Carr ME Jr. Brophy DF, et al. J Thromb Haemost. 2006 Feb;4(2):372-6. doi: 10.1111/j.1538-7836.2006.01731.x. J Thromb Haemost. 2006. PMID: 16420568 Free article.

10

Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following intravenous administration in hemophilia patients.

Agersø H, Brophy DF, Pelzer H, Martin EJ, Carr M, Hedner U, Ezban M. Agersø H, et al. Among authors: brophy df. J Thromb Haemost. 2011 Feb;9(2):333-8. doi: 10.1111/j.1538-7836.2010.04152.x. J Thromb Haemost. 2011. PMID: 21114621 Free PMC article.

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