Factor VIIa treatment increases circulating extracellular vesicles in hemophilia patients: Implications for the therapeutic hemostatic effect of FVIIa

J Thromb Haemost. 2022 Aug;20(8):1928-1933. doi: 10.1111/jth.15768. Epub 2022 Jun 6.

Authors

Kaushik Das¹, Usha R Pendurthi¹, Marylyn Manco-Johnson², Erika J Martin³, Donald F Brophy³, L Vijaya Mohan Rao¹

Affiliations

¹ Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
² School of Medicine, University of Colorado, Aurora, Colorado, USA.
³ Department of Pharmacotherapy & Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, USA.

No abstract available

Keywords: extracellular vesicles; factor VIIa; hemophilia; hemostasis; miR10a.

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Extracellular Vesicles*
Factor VIIa / pharmacology
Factor VIIa / therapeutic use
Hemophilia A* / drug therapy
Hemostasis
Hemostatics* / therapeutic use
Humans

Substances

Hemostatics
Factor VIIa

Grants and funding