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Page 1
High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs.
Knezevic L, Wachsmann TLA, Francis O, Dockree T, Bridgeman JS, Wouters A, de Wet B, Cole DK, Clement M, McLaren JE, Gostick E, Ladell K, Llewellyn-Lacey S, Price DA, van den Berg HA, Tabi Z, Sessions RB, Heemskerk MHM, Wooldridge L. Knezevic L, et al. Among authors: bridgeman js. J Biol Chem. 2023 Aug;299(8):104981. doi: 10.1016/j.jbc.2023.104981. Epub 2023 Jun 28. J Biol Chem. 2023. PMID: 37390984 Free PMC article.
Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes.
Kalaitsidou M, Moon OR, Sykorova M, Bao L, Qu Y, Sukumaran S, Valentine M, Zhou X, Pandey V, Foos K, Medvedev S, Powell DJ Jr, Udyavar A, Gschweng E, Rodriguez R, Dudley ME, Hawkins RE, Kueberuwa G, Bridgeman JS. Kalaitsidou M, et al. Among authors: bridgeman js. Front Immunol. 2023 Nov 7;14:1256491. doi: 10.3389/fimmu.2023.1256491. eCollection 2023. Front Immunol. 2023. PMID: 38022678 Free PMC article.
Clinical feasibility and treatment outcomes with nonselected autologous tumor-infiltrating lymphocyte therapy in patients with advanced cutaneous melanoma.
Pillai M, Jiang Y, Lorigan PC, Thistlethwaite FC, Thomas M, Kirillova N, Bridgeman JS, Kueberuwa G, Biswas S, Velazquez P, Chonzi D, Guest RD, Roberts ZJ, Hawkins RE. Pillai M, et al. Among authors: bridgeman js. Am J Cancer Res. 2022 Aug 15;12(8):3967-3984. eCollection 2022. Am J Cancer Res. 2022. PMID: 36119832 Free PMC article.
CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.
Clement M, Knezevic L, Dockree T, McLaren JE, Ladell K, Miners KL, Llewellyn-Lacey S, Rubina A, Francis O, Cole DK, Sewell AK, Bridgeman JS, Price DA, van den Berg HA, Wooldridge L. Clement M, et al. Among authors: bridgeman js. Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2019639118. doi: 10.1073/pnas.2019639118. Proc Natl Acad Sci U S A. 2021. PMID: 34272276 Free PMC article.
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells.
Pearson FE, Tullett KM, Leal-Rojas IM, Haigh OL, Masterman KA, Walpole C, Bridgeman JS, McLaren JE, Ladell K, Miners K, Llewellyn-Lacey S, Price DA, Tunger A, Schmitz M, Miles JJ, Lahoud MH, Radford KJ. Pearson FE, et al. Among authors: bridgeman js. Clin Transl Immunology. 2020 Jun 12;9(6):e1141. doi: 10.1002/cti2.1141. eCollection 2020. Clin Transl Immunology. 2020. PMID: 32547743 Free PMC article.
Massively parallel interrogation and mining of natively paired human TCRαβ repertoires.
Spindler MJ, Nelson AL, Wagner EK, Oppermans N, Bridgeman JS, Heather JM, Adler AS, Asensio MA, Edgar RC, Lim YW, Meyer EH, Hawkins RE, Cobbold M, Johnson DS. Spindler MJ, et al. Among authors: bridgeman js. Nat Biotechnol. 2020 May;38(5):609-619. doi: 10.1038/s41587-020-0438-y. Epub 2020 Mar 16. Nat Biotechnol. 2020. PMID: 32393905 Free PMC article.
ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells.
Mohammed RN, Wehenkel SC, Galkina EV, Yates EK, Preece G, Newman A, Watson HA, Ohme J, Bridgeman JS, Durairaj RRP, Moon OR, Ladell K, Miners KL, Dolton G, Troeberg L, Kashiwagi M, Murphy G, Nagase H, Price DA, Matthews RJ, Knäuper V, Ager A. Mohammed RN, et al. Among authors: bridgeman js. Sci Rep. 2019 Apr 2;9(1):5487. doi: 10.1038/s41598-019-41811-z. Sci Rep. 2019. PMID: 30940840 Free PMC article.
Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.
Cole DK, Fuller A, Dolton G, Zervoudi E, Legut M, Miles K, Blanchfield L, Madura F, Holland CJ, Bulek AM, Bridgeman JS, Miles JJ, Schauenburg AJA, Beck K, Evavold BD, Rizkallah PJ, Sewell AK. Cole DK, et al. Among authors: bridgeman js. Front Immunol. 2017 Nov 10;8:1503. doi: 10.3389/fimmu.2017.01503. eCollection 2017. Front Immunol. 2017. PMID: 29209312 Free PMC article.
CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains.
Chancellor A, Tocheva AS, Cave-Ayland C, Tezera L, White A, Al Dulayymi JR, Bridgeman JS, Tews I, Wilson S, Lissin NM, Tebruegge M, Marshall B, Sharpe S, Elliott T, Skylaris CK, Essex JW, Baird MS, Gadola S, Elkington P, Mansour S. Chancellor A, et al. Among authors: bridgeman js. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10956-E10964. doi: 10.1073/pnas.1708252114. Epub 2017 Nov 20. Proc Natl Acad Sci U S A. 2017. PMID: 29158404 Free PMC article.
28 results