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Is oral lipid-based delivery for drug targeting to the brain feasible?
Brookes A, Ji L, Bradshaw TD, Stocks M, Gray D, Butler J, Gershkovich P. Brookes A, et al. Among authors: bradshaw td. Eur J Pharm Biopharm. 2022 Mar;172:112-122. doi: 10.1016/j.ejpb.2022.02.004. Epub 2022 Feb 8. Eur J Pharm Biopharm. 2022. PMID: 35149190 Free article. Review.
Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.
Stone EL, Citossi F, Singh R, Kaur B, Gaskell M, Farmer PB, Monks A, Hose C, Stevens MF, Leong CO, Stocks M, Kellam B, Marlow M, Bradshaw TD. Stone EL, et al. Among authors: bradshaw td. Bioorg Med Chem. 2015 Nov 1;23(21):6891-9. doi: 10.1016/j.bmc.2015.09.052. Epub 2015 Oct 3. Bioorg Med Chem. 2015. PMID: 26474663
Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors.
Schwehm C, Kellam B, Garces AE, Hill SJ, Kindon ND, Bradshaw TD, Li J, Macdonald SJ, Rowedder JE, Stoddart LA, Stocks MJ. Schwehm C, et al. Among authors: bradshaw td. J Med Chem. 2017 Feb 23;60(4):1534-1554. doi: 10.1021/acs.jmedchem.6b01801. Epub 2017 Feb 10. J Med Chem. 2017. PMID: 28128944 Free article.
Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery.
Skilling KJ, Stocks MJ, Kellam B, Ashford M, Bradshaw TD, Burroughs L, Marlow M. Skilling KJ, et al. Among authors: bradshaw td. ChemMedChem. 2018 Jun 6;13(11):1098-1101. doi: 10.1002/cmdc.201800063. Epub 2018 May 8. ChemMedChem. 2018. PMID: 29570948
Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.
Lee JB, Zgair A, Malec J, Kim TH, Kim MG, Ali J, Qin C, Feng W, Chiang M, Gao X, Voronin G, Garces AE, Lau CL, Chan TH, Hume A, McIntosh TM, Soukarieh F, Al-Hayali M, Cipolla E, Collins HM, Heery DM, Shin BS, Yoo SD, Kagan L, Stocks MJ, Bradshaw TD, Fischer PM, Gershkovich P. Lee JB, et al. Among authors: bradshaw td. J Control Release. 2018 Sep 28;286:10-19. doi: 10.1016/j.jconrel.2018.07.022. Epub 2018 Jul 18. J Control Release. 2018. PMID: 30016732 Free PMC article.
Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer.
Garces AE, Al-Hayali M, Lee JB, Li J, Gershkovich P, Bradshaw TD, Stocks MJ. Garces AE, et al. Among authors: bradshaw td. ACS Med Chem Lett. 2019 Sep 27;11(3):316-321. doi: 10.1021/acsmedchemlett.9b00378. eCollection 2020 Mar 12. ACS Med Chem Lett. 2019. PMID: 32184963 Free PMC article.
132 results