Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery

Katherine J Skilling; Michael J Stocks; Barrie Kellam; Marianne Ashford; Tracey D Bradshaw; Laurence Burroughs; Maria Marlow

doi:10.1002/cmdc.201800063

Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery

ChemMedChem. 2018 Jun 6;13(11):1098-1101. doi: 10.1002/cmdc.201800063. Epub 2018 May 8.

Authors

Katherine J Skilling¹, Michael J Stocks¹, Barrie Kellam¹, Marianne Ashford², Tracey D Bradshaw¹, Laurence Burroughs¹, Maria Marlow¹

Affiliations

¹ School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
² Advanced Drug Delivery, Pharmaceutical Sciences, IMED Biotech, AstraZeneca, Macclesfield, UK.

PMID: 29570948
DOI: 10.1002/cmdc.201800063

Abstract

We have synthesized a range of gelators based on the nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and transmission electron microscopy. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the potential of nucleoside-based gelators for localized drug delivery.

Keywords: drug delivery; gels; gemcitabine; lamivudine; nucleosides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Deoxycytidine / administration & dosage
Deoxycytidine / analogs & derivatives*
Deoxycytidine / chemical synthesis
Deoxycytidine / chemistry
Deoxycytidine / pharmacology
Drug Delivery Systems*
Drug Screening Assays, Antitumor
Gels / chemical synthesis
Gels / chemistry
Gels / pharmacology*
Gemcitabine
Humans
Lamivudine / administration & dosage
Lamivudine / chemical synthesis
Lamivudine / chemistry
Lamivudine / pharmacology*
Microscopy, Electron, Transmission
Rheology
Viscoelastic Substances / chemical synthesis
Viscoelastic Substances / chemistry
Viscoelastic Substances / pharmacology

Substances

Gels
Viscoelastic Substances
Deoxycytidine
Lamivudine
Gemcitabine