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An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis.
Vugler A, O'Connell J, Nguyen MA, Weitz D, Leeuw T, Hickford E, Verbitsky A, Ying X, Rehberg M, Carrington B, Merriman M, Moss A, Nicholas JM, Stanley P, Wright S, Bourne T, Foricher Y, Brookings D, Horsley H, Herrmann M, Rao S, Kohlmann M, Florian P. Vugler A, et al. Among authors: bourne t. Front Pharmacol. 2022 Nov 16;13:1037983. doi: 10.3389/fphar.2022.1037983. eCollection 2022. Front Pharmacol. 2022. PMID: 36467083 Free PMC article.
Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation.
Novak A, Laughton D, Lane R, Blackham E, Thomas J, Chatzopoulou E, Wrigglesworth J, Quddus A, Ahmed S, Cousin D, Duffy L, Dubois N, Unitt J, Orban K, Browne E, Ward M, Mycock D, Ieva M, Bland N, George P, Bourne T, Asnagli H, Birch L, Jones G. Novak A, et al. Among authors: bourne t. J Med Chem. 2022 Dec 22;65(24):16640-16650. doi: 10.1021/acs.jmedchem.2c01446. Epub 2022 Nov 30. J Med Chem. 2022. PMID: 36449304
Investigating harms of testing for ovarian cancer - psychological outcomes and cancer conversion rates in women with symptoms of ovarian cancer: A cohort study embedded in the multicentre ROCkeTS prospective diagnostic study.
Kwong FL, Kristunas C, Davenport C, Aggarwal R, Deeks J, Mallett S, Kehoe S, Timmerman D, Bourne T, Stobart H, Neal R, Menon U, Gentry-Maharaj A, Sturdy L, Ottridge R, Sundar S; ROCkeTS collaborators. Kwong FL, et al. Among authors: bourne t. BJOG. 2024 Mar 31. doi: 10.1111/1471-0528.17813. Online ahead of print. BJOG. 2024. PMID: 38556698
Validation of ADNEX and IOTA two-step strategy and estimation of risk of complications during follow-up of adnexal masses in low-risk population.
Pascual MA, Vancraeynest L, Timmerman S, Ceusters J, Ledger A, Graupera B, Rodriguez I, Valero B, Landolfo C, Testa AC, Bourne T, Timmerman D, Valentin L, Van Calster B, Froyman W. Pascual MA, et al. Among authors: bourne t. Ultrasound Obstet Gynecol. 2024 Mar 13. doi: 10.1002/uog.27642. Online ahead of print. Ultrasound Obstet Gynecol. 2024. PMID: 38477179
Machine learning and radiomics for segmentation and classification of adnexal masses on ultrasound.
Barcroft JF, Linton-Reid K, Landolfo C, Al-Memar M, Parker N, Kyriacou C, Munaretto M, Fantauzzi M, Cooper N, Yazbek J, Bharwani N, Lee SR, Kim JH, Timmerman D, Posma J, Savelli L, Saso S, Aboagye EO, Bourne T. Barcroft JF, et al. Among authors: bourne t. NPJ Precis Oncol. 2024 Feb 20;8(1):41. doi: 10.1038/s41698-024-00527-8. NPJ Precis Oncol. 2024. PMID: 38378773 Free PMC article.
Beta-human chorionic gonadotrophin point of care testing for the management of pregnancy of unknown location.
Kyriacou C, Kapur S, Jeyapala S, Parker N, Yang W, Pikovsky M, Bobdiwala S, Barcroft J, Maheetharan S, Sur S, Stalder C, Gould D, Syed S, Tan T, Bourne T. Kyriacou C, et al. Among authors: bourne t. Reprod Biomed Online. 2024 Mar;48(3):103643. doi: 10.1016/j.rbmo.2023.103643. Epub 2023 Oct 22. Reprod Biomed Online. 2024. PMID: 38262209 Free article.
Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer: a multicentre external validation in patients who underwent surgery.
Landolfo C, Ceusters J, Valentin L, Froyman W, Van Gorp T, Heremans R, Baert T, Wouters R, Vankerckhoven A, Van Rompuy AS, Billen J, Moro F, Mascilini F, Neumann A, Van Holsbeke C, Chiappa V, Bourne T, Fischerova D, Testa A, Coosemans A, Timmerman D, Van Calster B. Landolfo C, et al. Among authors: bourne t. Br J Cancer. 2024 Apr;130(6):934-940. doi: 10.1038/s41416-024-02578-x. Epub 2024 Jan 19. Br J Cancer. 2024. PMID: 38243011
447 results