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Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi.
Lechuga GC, Borges JC, Calvet CM, de Araújo HP, Zuma AA, do Nascimento SB, Motta MCM, Bernardino AMR, Pereira MCS, Bourguignon SC. Lechuga GC, et al. Among authors: bourguignon sc. Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):154-164. doi: 10.1016/j.ijpddr.2016.07.001. Epub 2016 Jul 14. Int J Parasitol Drugs Drug Resist. 2016. PMID: 27490082 Free PMC article.
Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound.
Lara LS, Moreira CS, Calvet CM, Lechuga GC, Souza RS, Bourguignon SC, Ferreira VF, Rocha D, Pereira MCS. Lara LS, et al. Among authors: bourguignon sc. Eur J Med Chem. 2018 Jan 20;144:572-581. doi: 10.1016/j.ejmech.2017.12.052. Epub 2017 Dec 16. Eur J Med Chem. 2018. PMID: 29289882
The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis.
Gonçalves-Oliveira LF, Souza-Silva F, de Castro Côrtes LM, Veloso LB, Santini Pereira BA, Cysne-Finkelstein L, Lechuga GC, Bourguignon SC, Almeida-Souza F, da Silva Calabrese K, Ferreira VF, Alves CR. Gonçalves-Oliveira LF, et al. Among authors: bourguignon sc. Int J Parasitol Drugs Drug Resist. 2019 Aug;10:101-108. doi: 10.1016/j.ijpddr.2019.08.002. Epub 2019 Aug 12. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31430693 Free PMC article.
Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection.
Ferreira CM, Stiebler R, Saraiva FM, Lechuga GC, Walter-Nuno AB, Bourguignon SC, Gonzalez MS, Azambuja P, Gandara ACP, Menna-Barreto RFS, Paiva-Silva GO, Paes MC, Oliveira MF. Ferreira CM, et al. Among authors: bourguignon sc. PLoS Negl Trop Dis. 2018 Jul 23;12(7):e0006661. doi: 10.1371/journal.pntd.0006661. eCollection 2018 Jul. PLoS Negl Trop Dis. 2018. PMID: 30036366 Free PMC article.
Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease.
Monteiro ME, Lechuga G, Lara LS, Souto BA, Viganó MG, Bourguignon SC, Calvet CM, Oliveira FOR Jr, Alves CR, Souza-Silva F, Santos MS, Pereira MCS. Monteiro ME, et al. Among authors: bourguignon sc. Eur J Med Chem. 2019 Nov 15;182:111610. doi: 10.1016/j.ejmech.2019.111610. Epub 2019 Aug 10. Eur J Med Chem. 2019. PMID: 31434040
28 results