Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms

Alessandra Jorqueira; Robson M Gouvêa; Vitor F Ferreira; Milton N da Silva; Maria C B V de Souza; Aline A Zuma; Danielle F B Cavalcanti; Humberto P Araújo; Dilvani O Santos; Saulo C Bourguignon

doi:10.1007/s00436-006-0153-8

Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms

Parasitol Res. 2006 Sep;99(4):429-33. doi: 10.1007/s00436-006-0153-8. Epub 2006 Apr 5.

Authors

Alessandra Jorqueira¹, Robson M Gouvêa, Vitor F Ferreira, Milton N da Silva, Maria C B V de Souza, Aline A Zuma, Danielle F B Cavalcanti, Humberto P Araújo, Dilvani O Santos, Saulo C Bourguignon

Affiliation

¹ Departamento de Química Orgânica-PQO, Instituto de Química, Universidade Federal Fluminense, 24020-150, Niterói, Rio de Janeiro, Brazil.

PMID: 16596415
DOI: 10.1007/s00436-006-0153-8

Abstract

The investigation of trypanocidal effects against Trypanosoma cruzi and cytotoxicity in VERO cell line of several oxyranes structurally related to beta-lapachone, nor-beta-lapachone, alpha-lapachone, and 4-methoxy-1,2-naphthoquinone is described. It was found that the oxyranes 10 derived from alpha-lapachone showed an approximately the same trypanocidal activity of beta-lapachone. In addition, all the oxyranes showed less cytotoxicity than the corresponding naphthoquinones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / pharmacology*
Cell Survival / drug effects
Chlorocebus aethiops
Dose-Response Relationship, Drug
Fibroblasts / drug effects
Fibroblasts / pathology
Growth Inhibitors / pharmacology*
Naphthoquinones / chemistry
Naphthoquinones / pharmacology*
Trypanosoma cruzi / drug effects*
Trypanosoma cruzi / growth & development*
Vero Cells

Substances

Antiprotozoal Agents
Growth Inhibitors
Naphthoquinones
beta-lapachone
alpha-lapachone