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To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?
Zheng Y, Schroeder S, Kanev GK, Botros SS, William S, Sabra AA, Maes L, Caljon G, Gil C, Martinez A, Salado IG, Augustyns K, Edink E, Sijm M, de Heuvel E, de Esch IJP, van der Meer T, Siderius M, Sterk GJ, Brown D, Leurs R. Zheng Y, et al. Among authors: botros ss. Int J Mol Sci. 2023 Apr 6;24(7):6817. doi: 10.3390/ijms24076817. Int J Mol Sci. 2023. PMID: 37047792 Free PMC article.
Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.
Botros SS, William S, Sabra AA, El-Lakkany NM, Seif El-Din SH, García-Rubia A, Sebastián-Pérez V, Blaazer AR, de Heuvel E, Sijm M, Zheng Y, Salado IG, Munday JC, Maes L, de Esch IJP, Sterk GJ, Augustyns K, Leurs R, Gil C, De Koning HP. Botros SS, et al. Int J Parasitol Drugs Drug Resist. 2019 Apr;9:35-43. doi: 10.1016/j.ijpddr.2019.01.001. Epub 2019 Jan 14. Int J Parasitol Drugs Drug Resist. 2019. PMID: 30669086 Free PMC article.
Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.
Munday JC, Kunz S, Kalejaiye TD, Siderius M, Schroeder S, Paape D, Alghamdi AH, Abbasi Z, Huang SX, Donachie AM, William S, Sabra AN, Sterk GJ, Botros SS, Brown DG, Hoffman CS, Leurs R, de Koning HP. Munday JC, et al. Among authors: botros ss. PLoS Negl Trop Dis. 2020 Jul 30;14(7):e0008447. doi: 10.1371/journal.pntd.0008447. eCollection 2020 Jul. PLoS Negl Trop Dis. 2020. PMID: 32730343 Free PMC article.
Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools.
Sebastian-Perez V, García-Rubia A, Seif El-Din SH, Sabra AA, El-Lakkany NM, William S, Blundell TL, Maes L, Martinez A, Campillo NE, Botros SS, Gil C. Sebastian-Perez V, et al. Among authors: botros ss. J Enzyme Inhib Med Chem. 2020 Dec;35(1):511-523. doi: 10.1080/14756366.2020.1712595. J Enzyme Inhib Med Chem. 2020. PMID: 31939312 Free PMC article.
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
Botros SS, William S, Beadle JR, Valiaeva N, Hostetler KY. Botros SS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5284-7. doi: 10.1128/AAC.00840-09. Epub 2009 Aug 24. Antimicrob Agents Chemother. 2009. PMID: 19704122 Free PMC article.
67 results