Abstract
9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [(S)-HPMPA] has been reported to have antischistosomal activity. Ether lipid esters of (S)-HPMPA and cidofovir (CDV) have greatly increased activities in antiviral assays and in lethal animal models of poxvirus diseases. To see if ether lipid esters of CDV and (S)-HPMPA enhance antischistosomal activity, we tested their alkoxyalkyl esters using Schistosoma mansoni worm killing in vitro. Hexadecyloxypropyl (HDP)-cyclic-(S)-HPMPA and HDP-cyclic-CDV exhibited significant in vitro antischistosomal activities and may offer promise alone or in combination with praziquantel.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / analogs & derivatives*
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Adenine / chemistry
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Adenine / pharmacology
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Adenine / therapeutic use
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Animals
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Cricetinae
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Mesocricetus
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Molecular Structure
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Organophosphonates / chemistry
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Organophosphonates / pharmacology*
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Organophosphonates / therapeutic use*
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Schistosoma / drug effects*
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Schistosomiasis / drug therapy*
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Schistosomiasis / parasitology
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Schistosomicides / chemistry*
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Schistosomicides / pharmacology*
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Schistosomicides / therapeutic use*
Substances
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Organophosphonates
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Schistosomicides
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9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
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Adenine