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1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate.
Bond S, Draffan AG, Fenner JE, Lambert J, Lim CY, Lin B, Luttick A, Mitchell JP, Morton CJ, Nearn RH, Sanford V, Anderson KH, Mayes PA, Tucker SP. Bond S, et al. Bioorg Med Chem Lett. 2015 Feb 15;25(4):976-81. doi: 10.1016/j.bmcl.2014.11.024. Epub 2014 Nov 14. Bioorg Med Chem Lett. 2015. PMID: 25595685
Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agents.
Draffan AG, Frey B, Fraser BH, Pool B, Gannon C, Tyndall EM, Cianci J, Harding M, Lilly M, Hufton R, Halim R, Jahangiri S, Bond S, Jeynes TP, Nguyen VT, Wirth V, Luttick A, Tilmanis D, Pryor M, Porter K, Morton CJ, Lin B, Duan J, Bethell RC, Kukolj G, Simoneau B, Tucker SP. Draffan AG, et al. Among authors: bond s. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4984-8. doi: 10.1016/j.bmcl.2014.09.030. Epub 2014 Sep 21. Bioorg Med Chem Lett. 2014. PMID: 25288185
Prodrugs of imidazotriazine and pyrrolotriazine C-nucleosides can increase anti-HCV activity and enhance nucleotide triphosphate concentrations in vitro.
Tyndall EM, Draffan AG, Frey B, Pool B, Halim R, Jahangiri S, Bond S, Wirth V, Luttick A, Tilmanis D, Thomas J, Porter K, Tucker SP. Tyndall EM, et al. Among authors: bond s. Bioorg Med Chem Lett. 2015 Feb 15;25(4):869-73. doi: 10.1016/j.bmcl.2014.12.069. Epub 2014 Dec 30. Bioorg Med Chem Lett. 2015. PMID: 25592710
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
Draffan AG, Frey B, Pool B, Gannon C, Tyndall EM, Lilly M, Francom P, Hufton R, Halim R, Jahangiri S, Bond S, Nguyen VT, Jeynes TP, Wirth V, Luttick A, Tilmanis D, Thomas JD, Pryor M, Porter K, Morton CJ, Lin B, Duan J, Kukolj G, Simoneau B, McKercher G, Lagacé L, Amad M, Bethell RC, Tucker SP. Draffan AG, et al. Among authors: bond s. ACS Med Chem Lett. 2014 Apr 10;5(6):679-84. doi: 10.1021/ml500077j. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944743 Free PMC article.
698 results