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Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors.
Johansson NG, Dreano L, Vidilaseris K, Khattab A, Liu J, Lasbleiz A, Ribeiro O, Kiriazis A, Boije Af Gennäs G, Meri S, Goldman A, Yli-Kauhaluoma J, Xhaard H. Johansson NG, et al. Among authors: boije af gennas g. ChemMedChem. 2021 Nov 5;16(21):3360-3367. doi: 10.1002/cmdc.202100392. Epub 2021 Oct 12. ChemMedChem. 2021. PMID: 34459148 Free PMC article.
Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor.
Vidilaseris K, Kiriazis A, Turku A, Khattab A, Johansson NG, Leino TO, Kiuru PS, Boije Af Gennäs G, Meri S, Yli-Kauhaluoma J, Xhaard H, Goldman A. Vidilaseris K, et al. Among authors: boije af gennas g. Sci Adv. 2019 May 22;5(5):eaav7574. doi: 10.1126/sciadv.aav7574. eCollection 2019 May. Sci Adv. 2019. PMID: 31131322 Free PMC article.
Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment.
Johansson NG, Turku A, Vidilaseris K, Dreano L, Khattab A, Ayuso Pérez D, Wilkinson A, Zhang Y, Tamminen M, Grazhdankin E, Kiriazis A, Fishwick CWG, Meri S, Yli-Kauhaluoma J, Goldman A, Boije Af Gennäs G, Xhaard H. Johansson NG, et al. Among authors: boije af gennas g. ACS Med Chem Lett. 2020 Feb 17;11(4):605-610. doi: 10.1021/acsmedchemlett.9b00537. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292570 Free PMC article.
Adenosine analogs bearing phosphate isosteres as human MDO1 ligands.
Zhang Y, Jumppanen M, Maksimainen MM, Auno S, Awol Z, Ghemtio L, Venkannagari H, Lehtiö L, Yli-Kauhaluoma J, Xhaard H, Boije Af Gennäs G. Zhang Y, et al. Among authors: boije af gennas g. Bioorg Med Chem. 2018 May 1;26(8):1588-1597. doi: 10.1016/j.bmc.2018.02.006. Epub 2018 Feb 13. Bioorg Med Chem. 2018. PMID: 29501416
Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.
Provenzani R, Tarvainen I, Brandoli G, Lempinen A, Artes S, Turku A, Jäntti MH, Talman V, Yli-Kauhaluoma J, Tuominen RK, Boije Af Gennäs G. Provenzani R, et al. Among authors: boije af gennas g. PLoS One. 2018 Apr 11;13(4):e0195668. doi: 10.1371/journal.pone.0195668. eCollection 2018. PLoS One. 2018. PMID: 29641588 Free PMC article.
Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.
Jumppanen M, Kinnunen SM, Välimäki MJ, Talman V, Auno S, Bruun T, Boije Af Gennäs G, Xhaard H, Aumüller IB, Ruskoaho H, Yli-Kauhaluoma J. Jumppanen M, et al. Among authors: boije af gennas g. J Med Chem. 2019 Sep 12;62(17):8284-8310. doi: 10.1021/acs.jmedchem.9b01086. Epub 2019 Sep 3. J Med Chem. 2019. PMID: 31431011 Free PMC article.
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