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Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.
Prinzing B, Zebley CC, Petersen CT, Fan Y, Anido AA, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi SK, Alli S, Crawford JC, Riberdy JM, Park JJ, Zhou S, Velasquez MP, DeRenzo C, Lazzarotto CR, Tsai SQ, Vogel P, Pruett-Miller SM, Langfitt DM, Gottschalk S, Youngblood B, Krenciute G. Prinzing B, et al. Among authors: boi sk. Sci Transl Med. 2021 Nov 17;13(620):eabh0272. doi: 10.1126/scitranslmed.abh0272. Epub 2021 Nov 17. Sci Transl Med. 2021. PMID: 34788079 Free PMC article.
BATF targets T cell exhaustion for termination.
Boi SK, Lan X, Youngblood B. Boi SK, et al. Nat Immunol. 2021 Aug;22(8):936-938. doi: 10.1038/s41590-021-00978-2. Nat Immunol. 2021. PMID: 34282328 Free PMC article.
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.
Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James EA, Nepom GT, Youngblood B. Abdelsamed HA, et al. Among authors: boi sk. Nat Immunol. 2020 May;21(5):578-587. doi: 10.1038/s41590-020-0633-5. Epub 2020 Mar 30. Nat Immunol. 2020. PMID: 32231298 Free PMC article.
Epigenetic regulation of T cell adaptive immunity.
Frias AB, Boi SK, Lan X, Youngblood B. Frias AB, et al. Among authors: boi sk. Immunol Rev. 2021 Mar;300(1):9-21. doi: 10.1111/imr.12943. Epub 2021 Feb 28. Immunol Rev. 2021. PMID: 33644866 Free PMC article. Review.
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects.
Verma V, Jafarzadeh N, Boi S, Kundu S, Jiang Z, Fan Y, Lopez J, Nandre R, Zeng P, Alolaqi F, Ahmad S, Gaur P, Barry ST, Valge-Archer VE, Smith PD, Banchereau J, Mkrtichyan M, Youngblood B, Rodriguez PC, Gupta S, Khleif SN. Verma V, et al. Nat Immunol. 2021 Jan;22(1):53-66. doi: 10.1038/s41590-020-00818-9. Epub 2020 Nov 23. Nat Immunol. 2021. PMID: 33230330 Free PMC article.
Stem, Effector, and Hybrid States of Memory CD8+ T Cells.
Lugli E, Galletti G, Boi SK, Youngblood BA. Lugli E, et al. Among authors: boi sk. Trends Immunol. 2020 Jan;41(1):17-28. doi: 10.1016/j.it.2019.11.004. Epub 2019 Dec 4. Trends Immunol. 2020. PMID: 31810790 Free PMC article. Review.
Obesity diminishes response to PD-1-based immunotherapies in renal cancer.
Boi SK, Orlandella RM, Gibson JT, Turbitt WJ, Wald G, Thomas L, Buchta Rosean C, Norris KE, Bing M, Bertrand L, Gross BP, Makkouk A, Starenki D, Farag KI, Sorge RE, Brown JA, Gordetsky J, Yasin H, Garje R, Nandagopal L, Weiner GJ, Lubaroff DM, Arend RC, Li P, Zakharia Y, Yang E, Salem AK, Nepple K, Marquez-Lago TT, Norian LA. Boi SK, et al. J Immunother Cancer. 2020 Dec;8(2):e000725. doi: 10.1136/jitc-2020-000725. J Immunother Cancer. 2020. PMID: 33427691 Free PMC article.
Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans.
Galletti G, De Simone G, Mazza EMC, Puccio S, Mezzanotte C, Bi TM, Davydov AN, Metsger M, Scamardella E, Alvisi G, De Paoli F, Zanon V, Scarpa A, Camisa B, Colombo FS, Anselmo A, Peano C, Polletti S, Mavilio D, Gattinoni L, Boi SK, Youngblood BA, Jones RE, Baird DM, Gostick E, Llewellyn-Lacey S, Ladell K, Price DA, Chudakov DM, Newell EW, Casucci M, Lugli E. Galletti G, et al. Among authors: boi sk. Nat Immunol. 2020 Dec;21(12):1552-1562. doi: 10.1038/s41590-020-0791-5. Epub 2020 Oct 12. Nat Immunol. 2020. PMID: 33046887 Free PMC article.
18 results