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Statistical methods for analysis of high-throughput RNA interference screens.
Birmingham A, Selfors LM, Forster T, Wrobel D, Kennedy CJ, Shanks E, Santoyo-Lopez J, Dunican DJ, Long A, Kelleher D, Smith Q, Beijersbergen RL, Ghazal P, Shamu CE. Birmingham A, et al. Nat Methods. 2009 Aug;6(8):569-75. doi: 10.1038/nmeth.1351. Nat Methods. 2009. PMID: 19644458 Free PMC article. Review.
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
Shen JP, Zhao D, Sasik R, Luebeck J, Birmingham A, Bojorquez-Gomez A, Licon K, Klepper K, Pekin D, Beckett AN, Sanchez KS, Thomas A, Kuo CC, Du D, Roguev A, Lewis NE, Chang AN, Kreisberg JF, Krogan N, Qi L, Ideker T, Mali P. Shen JP, et al. Among authors: birmingham a. Nat Methods. 2017 Jun;14(6):573-576. doi: 10.1038/nmeth.4225. Epub 2017 Mar 20. Nat Methods. 2017. PMID: 28319113 Free PMC article.
The Power Decoder Simulator for the Evaluation of Pooled shRNA Screen Performance.
Stombaugh J, Licon A, Strezoska Ž, Stahl J, Anderson SB, Banos M, van Brabant Smith A, Birmingham A, Vermeulen A. Stombaugh J, et al. Among authors: birmingham a. J Biomol Screen. 2015 Sep;20(8):965-75. doi: 10.1177/1087057115576715. Epub 2015 Mar 16. J Biomol Screen. 2015. PMID: 25777298 Free PMC article.
Off-target effects by siRNA can induce toxic phenotype.
Fedorov Y, Anderson EM, Birmingham A, Reynolds A, Karpilow J, Robinson K, Leake D, Marshall WS, Khvorova A. Fedorov Y, et al. Among authors: birmingham a. RNA. 2006 Jul;12(7):1188-96. doi: 10.1261/rna.28106. Epub 2006 May 8. RNA. 2006. PMID: 16682561 Free PMC article.
NoiseMaker: simulated screens for statistical assessment.
Kwan P, Birmingham A. Kwan P, et al. Among authors: birmingham a. Bioinformatics. 2010 Oct 1;26(19):2484-5. doi: 10.1093/bioinformatics/btq457. Epub 2010 Aug 11. Bioinformatics. 2010. PMID: 20702398 Free PMC article.
141 results