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In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution.
Conforti P, Bocchi VD, Campus I, Scaramuzza L, Galimberti M, Lischetti T, Talpo F, Pedrazzoli M, Murgia A, Ferrari I, Cordiglieri C, Fasciani A, Arenas E, Felsenfeld D, Biella G, Besusso D, Cattaneo E. Conforti P, et al. Among authors: besusso d. Cell Rep Methods. 2022 Dec 19;2(12):100367. doi: 10.1016/j.crmeth.2022.100367. eCollection 2022 Dec 19. Cell Rep Methods. 2022. PMID: 36590694 Free PMC article.
Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1.
Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fucà E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E. Faedo A, et al. Among authors: besusso d. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1234-E1242. doi: 10.1073/pnas.1611473114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137879 Free PMC article.
Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes.
Conforti P, Besusso D, Bocchi VD, Faedo A, Cesana E, Rossetti G, Ranzani V, Svendsen CN, Thompson LM, Toselli M, Biella G, Pagani M, Cattaneo E. Conforti P, et al. Among authors: besusso d. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E762-E771. doi: 10.1073/pnas.1715865115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311338 Free PMC article.
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. Vezzoli E, et al. Among authors: besusso d. J Clin Invest. 2019 May 6;129(6):2390-2403. doi: 10.1172/JCI120616. eCollection 2019 May 6. J Clin Invest. 2019. PMID: 31063986 Free PMC article.
Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease.
Besusso D, Schellino R, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Bocchi VD, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A, Cattaneo E. Besusso D, et al. Stem Cell Reports. 2020 May 12;14(5):876-891. doi: 10.1016/j.stemcr.2020.03.018. Epub 2020 Apr 16. Stem Cell Reports. 2020. PMID: 32302555 Free PMC article.
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