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Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.
Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Soto Albrecht Y, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Zhang S, Cope H, Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Bram Y, Kidane Y, Priebe W, Emmett MR, Meller R, Demharter S, Stentoft-Hansen V, Salvatore M, Galeano D, Enguita FJ, Grabham P, Trovao NS, Singh U, Haltom J, Heise MT, Moorman NJ, Baxter VK, Madden EA, Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baylin SB, Wurtele ES, Moraes-Vieira PM, Taylor D, Mason CE, Schisler JC, Schwartz RE, Beheshti A, Wallace DC. Guarnieri JW, et al. Among authors: best sm. Sci Transl Med. 2023 Aug 9;15(708):eabq1533. doi: 10.1126/scitranslmed.abq1533. Epub 2023 Aug 9. Sci Transl Med. 2023. PMID: 37556555
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys.
Speranza E, Williamson BN, Feldmann F, Sturdevant GL, Pérez-Pérez L, Meade-White K, Smith BJ, Lovaglio J, Martens C, Munster VJ, Okumura A, Shaia C, Feldmann H, Best SM, de Wit E. Speranza E, et al. Among authors: best sm. Sci Transl Med. 2021 Jan 27;13(578):eabe8146. doi: 10.1126/scitranslmed.abe8146. Epub 2021 Jan 11. Sci Transl Med. 2021. PMID: 33431511 Free PMC article.
TARGETED DOWN REGULATION OF CORE MITOCHONDRIAL GENES DURING SARS-COV-2 INFECTION.
Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Albrecht YS, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Cope H, Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Kidane YH, Priebe W, Emmett MR, Meller R, Singh U, Bram Y, tenOever BR, Heise MT, Moorman NJ, Madden EA, Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baxter VK, Baylin SB, Wurtele ES, Moraes-Vieira PM, Taylor D, Mason CE, Schisler JC, Schwartz RE, Beheshti A, Wallace DC. Guarnieri JW, et al. Among authors: best sm. bioRxiv [Preprint]. 2022 Feb 22:2022.02.19.481089. doi: 10.1101/2022.02.19.481089. bioRxiv. 2022. PMID: 35233572 Free PMC article. Preprint.
Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques.
Speranza E, Purushotham JN, Port JR, Schwarz B, Flagg M, Williamson BN, Feldmann F, Singh M, Pérez-Pérez L, Sturdevant GL, Roberts LM, Carmody A, Schulz JE, van Doremalen N, Okumura A, Lovaglio J, Hanley PW, Shaia C, Germain RN, Best SM, Munster VJ, Bosio CM, de Wit E. Speranza E, et al. Among authors: best sm. Life Sci Alliance. 2022 Jan 17;5(4):e202101314. doi: 10.26508/lsa.202101314. Print 2022 Apr. Life Sci Alliance. 2022. PMID: 35039442 Free PMC article.
Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.
Robertson SJ, Bedard O, McNally KL, Shaia C, Clancy CS, Lewis M, Broeckel RM, Chiramel AI, Shannon JG, Sturdevant GL, Rosenke R, Anzick SL, Forte E, Preuss C, Baker CN, Harder JM, Brunton C, Munger S, Bruno DP, Lack JB, Leung JM, Shamsaddini A, Gardina P, Sturdevant DE, Sun J, Martens C, Holland SM, Rosenthal NA, Best SM. Robertson SJ, et al. Among authors: best sm. Nat Commun. 2023 Jul 25;14(1):4481. doi: 10.1038/s41467-023-40076-5. Nat Commun. 2023. PMID: 37491352 Free PMC article.
Is the third interferon a charm?
Best SM. Best SM. Sci Transl Med. 2015 Apr 22;7(284):284fs16. doi: 10.1126/scitranslmed.aaa2817. Epub 2015 Apr 22. Sci Transl Med. 2015. PMID: 25904738
K18-hACE2 mice develop respiratory disease resembling severe COVID-19.
Yinda CK, Port JR, Bushmaker T, Owusu IO, Avanzato VA, Fischer RJ, Schulz JE, Holbrook MG, Hebner MJ, Rosenke R, Thomas T, Marzi A, Best SM, de Wit E, Shaia C, van Doremalen N, Munster VJ. Yinda CK, et al. Among authors: best sm. bioRxiv [Preprint]. 2020 Aug 11:2020.08.11.246314. doi: 10.1101/2020.08.11.246314. bioRxiv. 2020. PMID: 32803199 Free PMC article. Updated. Preprint.
SARS-CoV-2 infection dynamics in lungs of African green monkeys.
Speranza E, Williamson BN, Feldmann F, Sturdevant GL, Pérez-Pérez L, Mead-White K, Smith BJ, Lovaglio J, Martens C, Munster VJ, Okumura A, Shaia C, Feldmann H, Best SM, de Wit E. Speranza E, et al. Among authors: best sm. bioRxiv [Preprint]. 2020 Aug 20:2020.08.20.258087. doi: 10.1101/2020.08.20.258087. bioRxiv. 2020. PMID: 32839775 Free PMC article. Updated. Preprint.
Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2.
Shi G, Chiramel AI, Li T, Lai KK, Kenney AD, Zani A, Eddy AC, Majdoul S, Zhang L, Dempsey T, Beare PA, Kar S, Yewdell JW, Best SM, Yount JS, Compton AA. Shi G, et al. Among authors: best sm. J Clin Invest. 2022 Dec 15;132(24):e160766. doi: 10.1172/JCI160766. J Clin Invest. 2022. PMID: 36264642 Free PMC article.
A Systems Approach Reveals MAVS Signaling in Myeloid Cells as Critical for Resistance to Ebola Virus in Murine Models of Infection.
Dutta M, Robertson SJ, Okumura A, Scott DP, Chang J, Weiss JM, Sturdevant GL, Feldmann F, Haddock E, Chiramel AI, Ponia SS, Dougherty JD, Katze MG, Rasmussen AL, Best SM. Dutta M, et al. Among authors: best sm. Cell Rep. 2017 Jan 17;18(3):816-829. doi: 10.1016/j.celrep.2016.12.069. Cell Rep. 2017. PMID: 28099857 Free PMC article.
238 results