Benada J - Search Results

1

Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress.

Larsen BD, Benada J, Yung PYK, Bell RAV, Pappas G, Urban V, Ahlskog JK, Kuo TT, Janscak P, Megeney LA, Elsässer SJ, Bartek J, Sørensen CS. Larsen BD, et al. Among authors: benada j. Science. 2022 Apr 29;376(6592):476-483. doi: 10.1126/science.abi6378. Epub 2022 Apr 28. Science. 2022. PMID: 35482866

2

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.

Macurek L, Benada J, Müllers E, Halim VA, Krejčíková K, Burdová K, Pecháčková S, Hodný Z, Lindqvist A, Medema RH, Bartek J. Macurek L, et al. Among authors: benada j. Cell Cycle. 2013 Jan 15;12(2):251-62. doi: 10.4161/cc.23057. Epub 2012 Jan 15. Cell Cycle. 2013. PMID: 23255129 Free PMC article.

3

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.

Kleiblova P, Shaltiel IA, Benada J, Ševčík J, Pecháčková S, Pohlreich P, Voest EE, Dundr P, Bartek J, Kleibl Z, Medema RH, Macurek L. Kleiblova P, et al. Among authors: benada j. J Cell Biol. 2013 May 13;201(4):511-21. doi: 10.1083/jcb.201210031. Epub 2013 May 6. J Cell Biol. 2013. PMID: 23649806 Free PMC article.

4

Polo-like kinase 1 inhibits DNA damage response during mitosis.

Benada J, Burdová K, Lidak T, von Morgen P, Macurek L. Benada J, et al. Cell Cycle. 2015;14(2):219-31. doi: 10.4161/15384101.2014.977067. Cell Cycle. 2015. PMID: 25607646 Free PMC article.

5

Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.

Pechackova S, Burdova K, Benada J, Kleiblova P, Jenikova G, Macurek L. Pechackova S, et al. Among authors: benada j. Oncotarget. 2016 Mar 22;7(12):14458-75. doi: 10.18632/oncotarget.7363. Oncotarget. 2016. PMID: 26883108 Free PMC article.

6

Overcoming Treatment Toxicity through Sequential Therapy.

Benada J, Ejlertsen B, Sørensen CS. Benada J, et al. Cancer Cell. 2019 Jun 10;35(6):821-822. doi: 10.1016/j.ccell.2019.05.006. Cancer Cell. 2019. PMID: 31185206 Free article.

7

A catalog of curated breast cancer genes.

Bose M, Benada J, Thatte JV, Kinalis S, Ejlertsen B, Nielsen FC, Sørensen CS, Rossing M. Bose M, et al. Among authors: benada j. Breast Cancer Res Treat. 2022 Jan;191(2):431-441. doi: 10.1007/s10549-021-06441-y. Epub 2021 Nov 10. Breast Cancer Res Treat. 2022. PMID: 34755241 Free PMC article.

8

WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity.

Elbæk CR, Petrosius V, Benada J, Erichsen L, Damgaard RB, Sørensen CS. Elbæk CR, et al. Among authors: benada j. Cell Rep. 2022 Jan 18;38(3):110261. doi: 10.1016/j.celrep.2021.110261. Cell Rep. 2022. PMID: 35045293 Free article.

9

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway.

Petrosius V, Benada J, Nielsen O, Schoof EM, Sørensen CS. Petrosius V, et al. Among authors: benada j. iScience. 2022 Dec 13;26(1):105806. doi: 10.1016/j.isci.2022.105806. eCollection 2023 Jan 20. iScience. 2022. PMID: 36632060 Free PMC article.

10

Self-inflicted DNA breaks in cell differentiation and cancer.

Benada J, Alsowaida D, Megeney LA, Sørensen CS. Benada J, et al. Trends Cell Biol. 2023 Oct;33(10):850-859. doi: 10.1016/j.tcb.2023.03.002. Epub 2023 Mar 28. Trends Cell Biol. 2023. PMID: 36997393 Review.

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