Overcoming Treatment Toxicity through Sequential Therapy

Jan Benada; Bent Ejlertsen; Claus Storgaard Sørensen

doi:10.1016/j.ccell.2019.05.006

Overcoming Treatment Toxicity through Sequential Therapy

Cancer Cell. 2019 Jun 10;35(6):821-822. doi: 10.1016/j.ccell.2019.05.006.

Authors

Jan Benada¹, Bent Ejlertsen², Claus Storgaard Sørensen³

Affiliations

¹ Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark.
² Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen O, Denmark.
³ Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark. Electronic address: claus.storgaard@bric.ku.dk.

PMID: 31185206
DOI: 10.1016/j.ccell.2019.05.006

Abstract

Combined inhibitions of PARP and DNA damage checkpoint have the potential for high anti-cancer efficacy, but concurrent inhibitions have been hampered by intolerable side effects. In this issue of Cancer Cell, Fang and colleagues (Fang et al., 2019) propose that sequential inhibitions of PARP and DNA damage checkpoint considerably widen the therapeutic window.

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MeSH terms

Cell Cycle Checkpoints
Cell Cycle Proteins
Humans
Neoplasms*
Nuclear Proteins
Poly(ADP-ribose) Polymerase Inhibitors*
Protein-Tyrosine Kinases

Substances

Cell Cycle Proteins
Nuclear Proteins
Poly(ADP-ribose) Polymerase Inhibitors
Protein-Tyrosine Kinases
WEE1 protein, human