Beachy PA - Search Results

1

Cellular and molecular mechanisms of Hedgehog signalling.

Zhang Y, Beachy PA. Zhang Y, et al. Among authors: beachy pa. Nat Rev Mol Cell Biol. 2023 Sep;24(9):668-687. doi: 10.1038/s41580-023-00591-1. Epub 2023 Mar 17. Nat Rev Mol Cell Biol. 2023. PMID: 36932157 Review.

2

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.

Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. Deshpande I, et al. Among authors: beachy pa. Nature. 2019 Jul;571(7764):284-288. doi: 10.1038/s41586-019-1355-4. Epub 2019 Jul 1. Nature. 2019. PMID: 31263273 Free PMC article.

3

Dispatched uses Na⁺ flux to power release of lipid-modified Hedgehog.

Wang Q, Asarnow DE, Ding K, Mann RK, Hatakeyama J, Zhang Y, Ma Y, Cheng Y, Beachy PA. Wang Q, et al. Among authors: beachy pa. Nature. 2021 Nov;599(7884):320-324. doi: 10.1038/s41586-021-03996-0. Epub 2021 Oct 27. Nature. 2021. PMID: 34707294 Free PMC article.

4

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.

Myers BR, Neahring L, Zhang Y, Roberts KJ, Beachy PA. Myers BR, et al. Among authors: beachy pa. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11141-E11150. doi: 10.1073/pnas.1717891115. Epub 2017 Dec 11. Proc Natl Acad Sci U S A. 2017. PMID: 29229834 Free PMC article.

5

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.

Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA. Zhang Y, et al. Among authors: beachy pa. Cell. 2018 Nov 15;175(5):1352-1364.e14. doi: 10.1016/j.cell.2018.10.026. Epub 2018 Nov 8. Cell. 2018. PMID: 30415841 Free PMC article.

6

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.

Zhang Y, Lu WJ, Bulkley DP, Liang J, Ralko A, Han S, Roberts KJ, Li A, Cho W, Cheng Y, Manglik A, Beachy PA. Zhang Y, et al. Among authors: beachy pa. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28838-28846. doi: 10.1073/pnas.2011560117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139559 Free PMC article.

7

Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.

Lim A, Shin K, Zhao C, Kawano S, Beachy PA. Lim A, et al. Among authors: beachy pa. Nat Cell Biol. 2014 Dec;16(12):1135-45. doi: 10.1038/ncb3057. Epub 2014 Nov 2. Nat Cell Biol. 2014. PMID: 25362352 Free PMC article.

8

The Hedgehog and Wnt signalling pathways in cancer.

Taipale J, Beachy PA. Taipale J, et al. Among authors: beachy pa. Nature. 2001 May 17;411(6835):349-54. doi: 10.1038/35077219. Nature. 2001. PMID: 11357142 Review.

9

Hedgehog signalling in prostate regeneration, neoplasia and metastasis.

Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA. Karhadkar SS, et al. Among authors: beachy pa. Nature. 2004 Oct 7;431(7009):707-12. doi: 10.1038/nature02962. Epub 2004 Sep 12. Nature. 2004. PMID: 15361885

10

Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma.

Shin K, Lim A, Odegaard JI, Honeycutt JD, Kawano S, Hsieh MH, Beachy PA. Shin K, et al. Among authors: beachy pa. Nat Cell Biol. 2014 May;16(5):469-78. doi: 10.1038/ncb2956. Epub 2014 Apr 20. Nat Cell Biol. 2014. PMID: 24747439 Free PMC article.

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