Barker G - Search Results

1

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1.

Beck EM, Parnell E, Cowley A, Porter A, Gillespie J, Robinson J, Robinson L, Pannifer AD, Hamon V, Jones P, Morrison A, McElroy S, Timmerman M, Rutjes H, Mahajan P, Wiejak J, Luchowska-Stańska U, Morgan D, Barker G, Rehmann H, Yarwood SJ. Beck EM, et al. Among authors: barker g. Cells. 2019 Nov 12;8(11):1425. doi: 10.3390/cells8111425. Cells. 2019. PMID: 31726720 Free PMC article.

2

The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation.

Barker G, Parnell E, van Basten B, Buist H, Adams DR, Yarwood SJ. Barker G, et al. J Cardiovasc Dev Dis. 2017 Dec 5;4(4):22. doi: 10.3390/jcdd4040022. J Cardiovasc Dev Dis. 2017. PMID: 29367551 Free PMC article. Review.

3

Selective small-molecule EPAC activators.

Luchowska-Stańska U, Morgan D, Yarwood SJ, Barker G. Luchowska-Stańska U, et al. Among authors: barker g. Biochem Soc Trans. 2019 Oct 31;47(5):1415-1427. doi: 10.1042/BST20190254. Biochem Soc Trans. 2019. PMID: 31671184 Free PMC article. Review.

4

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators.

Wang P, Luchowska-Stańska U, van Basten B, Chen H, Liu Z, Wiejak J, Whelan P, Morgan D, Lochhead E, Barker G, Rehmann H, Yarwood SJ, Zhou J. Wang P, et al. Among authors: barker g. J Med Chem. 2020 May 28;63(10):5159-5184. doi: 10.1021/acs.jmedchem.9b02094. Epub 2020 May 11. J Med Chem. 2020. PMID: 32340447

5

Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs.

Wiejak J, Luchowska-Stańska U, Wang P, Zhou J, Maffia P, Morgan D, Barker G, Yarwood SJ. Wiejak J, et al. Among authors: barker g. Sci Rep. 2022 Oct 5;12(1):16505. doi: 10.1038/s41598-022-20607-8. Sci Rep. 2022. PMID: 36198739 Free PMC article.

6

Lithiation Substitution of Unprotected Benzyltetrazoles.

Wong JYF, Lewandowska A, Trowse BR, Barker G. Wong JYF, et al. Among authors: barker g. Org Lett. 2019 Sep 6;21(17):7069-7072. doi: 10.1021/acs.orglett.9b02633. Epub 2019 Aug 26. Org Lett. 2019. PMID: 31449424

7

Batch Versus Flow Lithiation-Substitution of 1,3,4-Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry.

Wong JYF, Tobin JM, Vilela F, Barker G. Wong JYF, et al. Among authors: barker g. Chemistry. 2019 Sep 20;25(53):12439-12445. doi: 10.1002/chem.201902917. Epub 2019 Aug 29. Chemistry. 2019. PMID: 31361052

8

Gold(I)-catalysed direct thioetherifications using allylic alcohols: an experimental and computational study.

Herkert L, Green SL, Barker G, Johnson DG, Young PC, Macgregor SA, Lee AL. Herkert L, et al. Among authors: barker g. Chemistry. 2014 Sep 1;20(36):11540-8. doi: 10.1002/chem.201403293. Epub 2014 Jul 30. Chemistry. 2014. PMID: 25080400 Free PMC article.

9

New Synthetic Methodology for Drug-like Molecules.

Barker G, Rapposelli S. Barker G, et al. Molecules. 2023 Jul 26;28(15):5632. doi: 10.3390/molecules28155632. Molecules. 2023. PMID: 37570616 Free PMC article.

10

Gold(I)-catalysed one-pot synthesis of chromans using allylic alcohols and phenols.

Coutant E, Young PC, Barker G, Lee AL. Coutant E, et al. Among authors: barker g. Beilstein J Org Chem. 2013 Sep 4;9:1797-806. doi: 10.3762/bjoc.9.209. eCollection 2013. Beilstein J Org Chem. 2013. PMID: 24062845 Free PMC article.

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