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Year | Number of Results |
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CRISPR-Cas12a-mediated DNA clamping triggers target-strand cleavage.
Nat Chem Biol. 2022 Sep;18(9):1014-1022. doi: 10.1038/s41589-022-01082-8. Epub 2022 Jul 14.
Nat Chem Biol. 2022.
PMID: 35836018
Free PMC article.
ENDO-Pore: high-throughput linked-end mapping of single DNA cleavage events using nanopore sequencing.
Torres Montaguth OE, Cross SJ, Ingram KWA, Lee L, Diffin FM, Szczelkun MD.
Torres Montaguth OE, et al.
Nucleic Acids Res. 2021 Nov 18;49(20):e118. doi: 10.1093/nar/gkab727.
Nucleic Acids Res. 2021.
PMID: 34417616
Free PMC article.
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5' modifications to CRISPR-Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage.
Mullally G, van Aelst K, Naqvi MM, Diffin FM, Karvelis T, Gasiunas G, Siksnys V, Szczelkun MD.
Mullally G, et al.
Nucleic Acids Res. 2020 Jul 9;48(12):6811-6823. doi: 10.1093/nar/gkaa477.
Nucleic Acids Res. 2020.
PMID: 32496535
Free PMC article.
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The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a.
van Aelst K, Martínez-Santiago CJ, Cross SJ, Szczelkun MD.
van Aelst K, et al.
Genes (Basel). 2019 Feb 22;10(2):169. doi: 10.3390/genes10020169.
Genes (Basel). 2019.
PMID: 30813348
Free PMC article.
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