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Two tiered approaches combining alternative test methods and minimizing the use of reconstructed human cornea-like epithelium tests for the evaluation of eye irritation potency of test chemicals.
Ko KY, Jeon HL, Kim J, Kim TS, Hong YH, Jeong MK, Park KH, Kim BH, Park S, Jang WH, Cho SA, An S, Cho AR, Yi JS, Kim JY, Kim H, Lee JK, Park KS. Ko KY, et al. Among authors: an s. Toxicol In Vitro. 2020 Mar;63:104675. doi: 10.1016/j.tiv.2019.104675. Epub 2019 Oct 22. Toxicol In Vitro. 2020. PMID: 31648046
Pre-validation study of spectrophotometric direct peptide reactivity assay (Spectro-DPRA) as a modified in chemico skin sensitization test method.
Seo JA, Cho SA, Park CE, Seo DH, Choi M, An S, Kim BH. Seo JA, et al. Among authors: an s. Toxicol Res. 2022 Jun 4;38(4):531-544. doi: 10.1007/s43188-022-00130-8. eCollection 2022 Oct. Toxicol Res. 2022. PMID: 36277359 Free PMC article.
Direct peptide reactivity assay (DPRA) has been adopted by the OECD as an alternative method to evaluate skin sensitization by assessing a substance's reaction to two model peptides. ...The reproducibility among the three laboratories was as high as 86.7%; the accur …
Direct peptide reactivity assay (DPRA) has been adopted by the OECD as an alternative method to evaluate skin sensitization by assess …
4,027 results