Alvarez JC - Search Results

1

Structure-based design of estrogen receptor-beta selective ligands.

Manas ES, Unwalla RJ, Xu ZB, Malamas MS, Miller CP, Harris HA, Hsiao C, Akopian T, Hum WT, Malakian K, Wolfrom S, Bapat A, Bhat RA, Stahl ML, Somers WS, Alvarez JC. Manas ES, et al. Among authors: alvarez jc. J Am Chem Soc. 2004 Nov 24;126(46):15106-19. doi: 10.1021/ja047633o. J Am Chem Soc. 2004. PMID: 15548008

2

Critical evaluation of methods to incorporate entropy loss upon binding in high-throughput docking.

Salaniwal S, Manas ES, Alvarez JC, Unwalla RJ. Salaniwal S, et al. Among authors: alvarez jc. Proteins. 2007 Feb 1;66(2):422-35. doi: 10.1002/prot.21180. Proteins. 2007. PMID: 17068803

3

Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.

Kaila N, Somers WS, Thomas BE, Thakker P, Janz K, DeBernardo S, Tam S, Moore WJ, Yang R, Wrona W, Bedard PW, Crommie D, Keith JC Jr, Tsao DH, Alvarez JC, Ni H, Marchese E, Patton JT, Magnani JL, Camphausen RT. Kaila N, et al. Among authors: alvarez jc. J Med Chem. 2005 Jun 30;48(13):4346-57. doi: 10.1021/jm050049l. J Med Chem. 2005. PMID: 15974587

4

High-throughput docking as a source of novel drug leads.

Alvarez JC. Alvarez JC. Curr Opin Chem Biol. 2004 Aug;8(4):365-70. doi: 10.1016/j.cbpa.2004.05.001. Curr Opin Chem Biol. 2004. PMID: 15288245 Review.

5

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.

Sutherland AG, Alvarez J, Ding W, Foreman KW, Kenny CH, Labthavikul P, Mosyak L, Petersen PJ, Rush TS 3rd, Ruzin A, Tsao DH, Wheless KL. Sutherland AG, et al. Org Biomol Chem. 2003 Dec 7;1(23):4138-40. doi: 10.1039/b312016c. Epub 2003 Oct 29. Org Biomol Chem. 2003. PMID: 14685315

6

Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

McKew JC, Lovering F, Clark JD, Bemis J, Xiang Y, Shen M, Zhang W, Alvarez JC, Joseph-McCarthy D. McKew JC, et al. Among authors: alvarez jc. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4501-4. doi: 10.1016/j.bmcl.2003.08.070. Bioorg Med Chem Lett. 2003. PMID: 14643356

7

Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors.

Kaila N, Thomas BE 4th, Thakker P, Alvarez JC, Camphausen RT, Crommie D. Kaila N, et al. Among authors: alvarez jc. Bioorg Med Chem Lett. 2001 Jan 22;11(2):151-5. doi: 10.1016/s0960-894x(00)00623-5. Bioorg Med Chem Lett. 2001. PMID: 11206447

8

Beta-C-mannosides as selectin inhibitors.

Kaila N, Chen L, Thomas BE 4th, Tsao D, Tam S, Bedard PW, Camphausen RT, Alvarez JC, Ullas G. Kaila N, et al. Among authors: alvarez jc. J Med Chem. 2002 Apr 11;45(8):1563-6. doi: 10.1021/jm010390f. J Med Chem. 2002. PMID: 11931610

9

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.

Tsao DH, Sutherland AG, Jennings LD, Li Y, Rush TS 3rd, Alvarez JC, Ding W, Dushin EG, Dushin RG, Haney SA, Kenny CH, Malakian AK, Nilakantan R, Mosyak L. Tsao DH, et al. Among authors: alvarez jc. Bioorg Med Chem. 2006 Dec 1;14(23):7953-61. doi: 10.1016/j.bmc.2006.07.050. Epub 2006 Aug 17. Bioorg Med Chem. 2006. PMID: 16919463

10

Pharmacophore-based molecular docking to account for ligand flexibility.

Joseph-McCarthy D, Thomas BE 4th, Belmarsh M, Moustakas D, Alvarez JC. Joseph-McCarthy D, et al. Among authors: alvarez jc. Proteins. 2003 May 1;51(2):172-88. doi: 10.1002/prot.10266. Proteins. 2003. PMID: 12660987

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