Abstract
The design and synthesis of novel beta-C-mannosides that inhibit the binding of sialyl Lewis x to E-selectin are described. Compounds that contained a phenyl substituent at the C-6 position were found to have increased potency.
MeSH terms
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Binding Sites
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Carbohydrate Sequence
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Drug Design
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E-Selectin / drug effects*
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Humans
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Inhibitory Concentration 50
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Mannosides / chemical synthesis
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Mannosides / metabolism
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Mannosides / pharmacology
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Models, Molecular
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Molecular Mimicry
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Molecular Sequence Data
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Oligosaccharides / chemical synthesis*
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Oligosaccharides / metabolism
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Oligosaccharides / pharmacology*
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Protein Binding / drug effects
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Sialyl Lewis X Antigen
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Structure-Activity Relationship
Substances
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E-Selectin
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Mannosides
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Oligosaccharides
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Sialyl Lewis X Antigen