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MELK is a novel therapeutic target in high-risk neuroblastoma.
Guan S, Lu J, Zhao Y, Yu Y, Li H, Chen Z, Shi Z, Liang H, Wang M, Guo K, Chen X, Sun W, Bieerkehazhi S, Xu X, Sun S, Agarwal S, Yang J. Guan S, et al. Among authors: agarwal s. Oncotarget. 2017 Dec 20;9(2):2591-2602. doi: 10.18632/oncotarget.23515. eCollection 2018 Jan 5. Oncotarget. 2017. PMID: 29416794 Free PMC article.
EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma.
Sun W, Rojas Y, Wang H, Yu Y, Wang Y, Chen Z, Rajapakshe K, Xu X, Huang W, Agarwal S, Patel RH, Woodfield S, Zhao Y, Jin J, Zhang H, Major A, Hicks MJ, Shohet JM, Vasudevan SA, Coarfa C, Yang J, Nuchtern JG. Sun W, et al. Among authors: agarwal s. Oncotarget. 2017 Oct 19;8(55):94780-94792. doi: 10.18632/oncotarget.21933. eCollection 2017 Nov 7. Oncotarget. 2017. PMID: 29212266 Free PMC article.
MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.
Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Barbieri E, Koster J, Perini G, Coarfa C, Shohet JM. Agarwal S, et al. Oncotarget. 2018 Apr 17;9(29):20323-20338. doi: 10.18632/oncotarget.24859. eCollection 2018 Apr 17. Oncotarget. 2018. PMID: 29755654 Free PMC article.
Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.
Li H, Yu Y, Zhao Y, Wu D, Yu X, Lu J, Chen Z, Zhang H, Hu Y, Zhai Y, Su J, Aheman A, De Las Casas A, Jin J, Xu X, Shi Z, Woodfield SE, Vasudevan SA, Agarwal S, Yan Y, Yang J, Foster JH. Li H, et al. Among authors: agarwal s. Cancer Lett. 2019 Aug 10;457:129-141. doi: 10.1016/j.canlet.2019.05.011. Epub 2019 May 14. Cancer Lett. 2019. PMID: 31100410
MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma.
Zhang S, Wei JS, Li SQ, Badgett TC, Song YK, Agarwal S, Coarfa C, Tolman C, Hurd L, Liao H, He J, Wen X, Liu Z, Thiele CJ, Westermann F, Asgharzadeh S, Seeger RC, Maris JM, Guidry Auvil JM, Smith MA, Kolaczyk ED, Shohet J, Khan J. Zhang S, et al. Among authors: agarwal s. Cancer Lett. 2016 Feb 28;371(2):214-24. doi: 10.1016/j.canlet.2015.11.045. Epub 2015 Dec 10. Cancer Lett. 2016. PMID: 26683771 Free PMC article.
6,918 results