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Is the time right for in vitro neurotoxicity testing using human iPSC-derived neurons?
Tukker AM, de Groot MW, Wijnolts FM, Kasteel EE, Hondebrink L, Westerink RH. Tukker AM, et al. ALTEX. 2016;33(3):261-71. doi: 10.14573/altex.1510091. Epub 2016 Mar 24. ALTEX. 2016. PMID: 27010910 Free article.
While human iPSC-derived neuronal cultures appear not yet suitable to fully replace the rat primary cortical model, our data indicate that these rapidly differentiating, commercially available human iPSC-derived neuronal cultures are already suitable for in vitro prioritis …
While human iPSC-derived neuronal cultures appear not yet suitable to fully replace the rat primary cortical model, our data indicate …
Towards animal-free neurotoxicity screening: Applicability of hiPSC-derived neuronal models for in vitro seizure liability assessment.
Tukker AM, Van Kleef RGDM, Wijnolts FMJ, De Groot A, Westerink RHS. Tukker AM, et al. ALTEX. 2020;37(1):121-135. doi: 10.14573/altex.1907121. Epub 2019 Nov 2. ALTEX. 2020. PMID: 31686111 Free article.
The increasing number of commercially available human induced pluripotent stem cell (hiPSC)-derived neuronal models holds great promise for replacing rodent primary cultures. We therefore tested three different hiPSC-derived neuronal models for their applicability for in v …
The increasing number of commercially available human induced pluripotent stem cell (hiPSC)-derived neuronal models holds great promise for …