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Distribution of optrA and cfr in florfenicol-resistant Staphylococcus sciuri of pig origin.
Fan R, Li D, Feßler AT, Wu C, Schwarz S, Wang Y. Fan R, et al. Vet Microbiol. 2017 Oct;210:43-48. doi: 10.1016/j.vetmic.2017.07.030. Epub 2017 Sep 1. Vet Microbiol. 2017. PMID: 29103695
Nine and six different arrangements of the optrA and cfr gene regions, respectively, were identified among the isolates. The arrangements optrA-araC-Tn558 or optrA-deltaTn558 were present in all optrA-positive isolates, and in three of them, ISEnfa5 an …
Nine and six different arrangements of the optrA and cfr gene regions, respectively, were identified among the isolates. The arrangem …
Rapid emergence of highly variable and transferable oxazolidinone and phenicol resistance gene optrA in German Enterococcus spp. clinical isolates.
Bender JK, Fleige C, Lange D, Klare I, Werner G. Bender JK, et al. Int J Antimicrob Agents. 2018 Dec;52(6):819-827. doi: 10.1016/j.ijantimicag.2018.09.009. Epub 2018 Sep 17. Int J Antimicrob Agents. 2018. PMID: 30236952
Multiple optrA variants were detected. The originally described variant from China (optrA(WT)) was the only variant shared between the two Enterococcus spp.; however, distinct optrA(WT) loci were detected for E. faecium and E. faecalis. Generally, optrA …
Multiple optrA variants were detected. The originally described variant from China (optrA(WT)) was the only variant shared bet …
Validating a screening agar for linezolid-resistant enterococci.
Werner G, Fleige C, Klare I, Weber RE, Bender JK. Werner G, et al. BMC Infect Dis. 2019 Dec 23;19(1):1078. doi: 10.1186/s12879-019-4711-y. BMC Infect Dis. 2019. PMID: 31870418 Free PMC article.
The collection of linezolid-resistant enterococcal control strains included isolates with different resistance mechanisms (23S rDNA mutations, cfr(B), optrA, poxtA). Finally, we validated our LRE screening agar with 400 samples sent to our National Reference Centre in 2019 …
The collection of linezolid-resistant enterococcal control strains included isolates with different resistance mechanisms (23S rDNA mutation …
Development of a multiplex-PCR to simultaneously detect acquired linezolid resistance genes cfr, optrA and poxtA in enterococci of clinical origin.
Bender JK, Fleige C, Klare I, Werner G. Bender JK, et al. J Microbiol Methods. 2019 May;160:101-103. doi: 10.1016/j.mimet.2019.03.025. Epub 2019 Mar 30. J Microbiol Methods. 2019. PMID: 30940534
Linezolid-resistant enterococcus spp. are increasingly recognized by diagnostic laboratories. Resistance can be mediated by the expression of cfr, optrA or poxtA. We developed a multiplex-PCR to simultaneously detect all three genes. ...
Linezolid-resistant enterococcus spp. are increasingly recognized by diagnostic laboratories. Resistance can be mediated by the expression o …
Linezolid Resistance Genes and Mutations among Linezolid-Susceptible Enterococcus spp.-A Loose Cannon?
Bender JK, Fleige C, Funk F, Moretó-Castellsagué C, Fischer MA, Werner G. Bender JK, et al. Antibiotics (Basel). 2024 Jan 19;13(1):101. doi: 10.3390/antibiotics13010101. Antibiotics (Basel). 2024. PMID: 38275330 Free PMC article.
Linezolid (LIN) resistance is mediated by G2576T 23S rDNA gene mutations and/or acquisition of resistance genes (cfr, optrA, poxtA). There are anecdotal reports that those resistance traits may be present in phenotypically linezolid-susceptible isolates. ...
Linezolid (LIN) resistance is mediated by G2576T 23S rDNA gene mutations and/or acquisition of resistance genes (cfr, optrA, poxtA). …
CHROMAgar™ LIN-R as an efficient screening tool to assess the prevalence of linezolid-resistant enterococci in German hospital patients-a multicentre study approach, 2021-2022.
Bender JK, Baufeld E, Becker K, Claus H, Dudakova A, Dörre A, Fila N, Fleige C, Hamprecht A, Hoffmann A, Hogardt M, Kaasch AJ, Kola A, Kriebel N, Layer-Nicolaou F, Marschal M, Molitor E, Mutters NT, Liese J, Nelkenbrecher C, Neumann B, Rohde H, Steinmann J, Sörensen M, Thelen P, Weig M, Zautner AE, Werner G. Bender JK, et al. J Antimicrob Chemother. 2023 Sep 5;78(9):2185-2191. doi: 10.1093/jac/dkad218. J Antimicrob Chemother. 2023. PMID: 37473450 Free PMC article.
At the NRC, linezolid resistance was determined by broth microdilution, multiplex-PCR for cfr/optrA/poxtA and by a restriction-based assay for 23S rDNA mutations. ...Most of LR-E. faecium 53/81 (65%) exhibited a 23S rRNA gene mutation as the sole resistance-mediating mecha …
At the NRC, linezolid resistance was determined by broth microdilution, multiplex-PCR for cfr/optrA/poxtA and by a restriction-based …
Prevalence and transmission of antimicrobial-resistant Staphylococci and Enterococci from shared bicycles in Chengdu, China.
Gu J, Xie XJ, Liu JX, Shui JR, Zhang HY, Feng GY, Liu XY, Li LC, Lan QW, Jin QH, Li R, Peng L, Lei CW, Zhang AY. Gu J, et al. Sci Total Environ. 2020 Oct 10;738:139735. doi: 10.1016/j.scitotenv.2020.139735. Epub 2020 May 27. Sci Total Environ. 2020. PMID: 32531590
Whole genome sequencing further characterized 26 antimicrobial resistance genes (ARGs) including fosB, fusB, and lnu(G) in S. aureus and 21 ARGs including optrA in Enterococci. Leveraging a complementary approach with conventional MLST, whole genome SNP and MLST analyses, …
Whole genome sequencing further characterized 26 antimicrobial resistance genes (ARGs) including fosB, fusB, and lnu(G) in S. aureus and 21 …
Dairy farm soil presents distinct microbiota and varied prevalence of antibiotic resistance across housing areas.
Liu J, Zhao Z, Avillan JJ, Call DR, Davis M, Sischo WM, Zhang A. Liu J, et al. Environ Pollut. 2019 Nov;254(Pt B):113058. doi: 10.1016/j.envpol.2019.113058. Epub 2019 Aug 14. Environ Pollut. 2019. PMID: 31454571 Free PMC article.
Thirty-two specific antibiotic resistance genes (ARGs) were widely distributed on dairies, of which several clinically relevant ARGs (including cfr, cfrB, and optrA) were identified for the first time at U.S. dairies. Overall, ARGs were observed more frequently in feces an …
Thirty-two specific antibiotic resistance genes (ARGs) were widely distributed on dairies, of which several clinically relevant ARGs (includ …
Evolution of Antibiotic Resistance of Coagulase-Negative Staphylococci Isolated from Healthy Turkeys in Egypt: First Report of Linezolid Resistance.
Moawad AA, Hotzel H, Awad O, Roesler U, Hafez HM, Tomaso H, Neubauer H, El-Adawy H. Moawad AA, et al. Microorganisms. 2019 Oct 22;7(10):476. doi: 10.3390/microorganisms7100476. Microorganisms. 2019. PMID: 31652567 Free PMC article.
The presence of resistance-associated genes like mecA, vanA, blaZ, erm(A), erm(B), erm(C), aac-aphD, optrA, valS, and cfr was determined. Thirty-nine CoNS were identified. ...This is the first study revealing the correlation between linezolid resistance and presence of cfr …
The presence of resistance-associated genes like mecA, vanA, blaZ, erm(A), erm(B), erm(C), aac-aphD, optrA, valS, and cfr was determi …