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β-Sitosterol suppresses hepatocellular carcinoma growth and metastasis via FOXM1-regulated Wnt/β-catenin pathway.
Chen Y, Yang Y, Wang N, Liu R, Wu Q, Pei H, Li W. Chen Y, et al. Among authors: pei h. J Cell Mol Med. 2024 Feb;28(3):e18072. doi: 10.1111/jcmm.18072. Epub 2023 Dec 8. J Cell Mol Med. 2024. PMID: 38063438 Free PMC article.
Mechanistically, beta-sitosterol inhibits Wnt/beta-catenin signalling by downregulating FOXM1, regulating target gene transcription related to HepG2 cell proliferation and metastasis. beta-Sitosterol shows promising potential as a therapeutic candidate for inhibiting HCC g …
Mechanistically, beta-sitosterol inhibits Wnt/beta-catenin signalling by downregulating FOXM1, regulating target gene transcription related …
Potentialities of Ganoderma lucidum extracts as functional ingredients in food formulation.
Sharif Swallah M, Bondzie-Quaye P, Wang H, Shao CS, Hua P, Alrasheed Bashir M, Benjamin Holman J, Sossah FL, Huang Q. Sharif Swallah M, et al. Among authors: hua p. Food Res Int. 2023 Oct;172:113161. doi: 10.1016/j.foodres.2023.113161. Epub 2023 Jun 18. Food Res Int. 2023. PMID: 37689913 Review.
Owing to the recognized therapeutic characteristics of G. lucidum, it is one of the most extensively researched mushrooms as a chemopreventive agent and as a functional food. It is a known wood-degrading basidiomycete possessing numerous pharmacological functions and is te …
Owing to the recognized therapeutic characteristics of G. lucidum, it is one of the most extensively researched mushrooms as a chemop …
Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases.
Dai Z, Zhang XN, Nasertorabi F, Cheng Q, Li J, Katz BB, Smbatyan G, Pei H, Louie SG, Lenz HJ, Stevens RC, Zhang Y. Dai Z, et al. Among authors: pei h. Sci Adv. 2020 Jun 3;6(23):eaba6752. doi: 10.1126/sciadv.aba6752. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32537509 Free PMC article.
Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases.
Kim HS, Hariri K, Zhang XN, Chen LC, Katz BB, Pei H, Louie SG, Zhang Y. Kim HS, et al. Among authors: pei h. Protein Sci. 2024 Apr;33(4):e4924. doi: 10.1002/pro.4924. Protein Sci. 2024. PMID: 38501590
This work demonstrates a new strategy for developing site-specific FDCs. It may be applicable to different antibody scaffolds for therapeutic conjugations, leading to novel targeted agents....
This work demonstrates a new strategy for developing site-specific FDCs. It may be applicable to different antibody scaffolds for therape …
Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin.
Sheng X, Parmentier JH, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright CM, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD. Sheng X, et al. Among authors: pei h. Mol Cancer Res. 2017 Dec;15(12):1704-1713. doi: 10.1158/1541-7786.MCR-17-0338. Epub 2017 Nov 8. Mol Cancer Res. 2017. PMID: 29117945 Free PMC article.
To our knowledge, this is the first demonstration that adipocytes metabolize and inactivate a therapeutic drug. Adipocyte-mediated daunorubicin metabolism reduces active drug concentration in the TME. ...
To our knowledge, this is the first demonstration that adipocytes metabolize and inactivate a therapeutic drug. Adipocyte-mediated da …
19 results