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A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1.
De Luca A, Parker LJ, Ang WH, Rodolfo C, Gabbarini V, Hancock NC, Palone F, Mazzetti AP, Menin L, Morton CJ, Parker MW, Lo Bello M, Dyson PJ. De Luca A, et al. Among authors: lo bello m. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):13943-13951. doi: 10.1073/pnas.1903297116. Epub 2019 Jun 20. Proc Natl Acad Sci U S A. 2019. PMID: 31221747 Free PMC article.
Rational design of an organometallic glutathione transferase inhibitor.
Ang WH, Parker LJ, De Luca A, Juillerat-Jeanneret L, Morton CJ, Lo Bello M, Parker MW, Dyson PJ. Ang WH, et al. Among authors: lo bello m. Angew Chem Int Ed Engl. 2009;48(21):3854-7. doi: 10.1002/anie.200900185. Angew Chem Int Ed Engl. 2009. PMID: 19396894 Free article.
Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.
Parker LJ, Italiano LC, Morton CJ, Hancock NC, Ascher DB, Aitken JB, Harris HH, Campomanes P, Rothlisberger U, De Luca A, Lo Bello M, Ang WH, Dyson PJ, Parker MW. Parker LJ, et al. Among authors: lo bello m. Chemistry. 2011 Jul 4;17(28):7806-16. doi: 10.1002/chem.201100586. Epub 2011 Jun 16. Chemistry. 2011. PMID: 21681839