Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure.
Sasset L, Manzo OL, Zhang Y, Marino A, Rubinelli L, Riemma MA, Chalasani MLS, Dasoveanu DC, Roviezzo F, Jankauskas SS, Santulli G, Bucci MR, Lu TT, Di Lorenzo A.
Sasset L, et al.
Cardiovasc Res. 2023 Mar 31;119(2):506-519. doi: 10.1093/cvr/cvac108.
Cardiovasc Res. 2023.
PMID: 35815623
Free PMC article.
Recently, we discovered that Nogo-B, a membrane protein of endoplasmic reticulum, abundant in the vascular wall, down-regulates the sphingolipid de novo biosynthesis via serine palmitoyltransferase (SPT), first and rate liming enzyme, to impact vascular functions and blood …
Recently, we discovered that Nogo-B, a membrane protein of endoplasmic reticulum, abundant in the vascular wall, down-regulates the sphingol …