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In vivo stability of ester- and ether-linked phospholipid-containing liposomes as measured by perturbed angular correlation spectroscopy.
Derksen JT, Baldeschwieler JD, Scherphof GL. Derksen JT, et al. Proc Natl Acad Sci U S A. 1988 Dec;85(24):9768-72. doi: 10.1073/pnas.85.24.9768. Proc Natl Acad Sci U S A. 1988. PMID: 3200855 Free PMC article.
To evaluate liposome formulations for use as intracellular sustained-release drug depots, we have compared the uptake and degradation in rat liver and spleen of liposomes of various compositions, containing as their bulk phospholipid an ether-linked phospholipid or one of several …
To evaluate liposome formulations for use as intracellular sustained-release drug depots, we have compared the uptake and degradation in rat …
Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages.
Derksen JT, Morselt HW, Scherphof GL. Derksen JT, et al. Biochim Biophys Acta. 1987 Oct 22;931(1):33-40. doi: 10.1016/0167-4889(87)90047-4. Biochim Biophys Acta. 1987. PMID: 3651512
During incubation in plasma, however, substantial proportions of both the cholesterol and the oleate are shed from the cells, predominantly in the unesterified form. When the liposomes are labeled with the cholesteryl ester analog [3H]cholesteryl hexadecylether only a very …
During incubation in plasma, however, substantial proportions of both the cholesterol and the oleate are shed from the cells, predominantly …
Delivery of liposome-associated drugs to liver cells.
Scherphof GL, Spanjer HH, Derksen JT, Kuipers F, Vonk RJ, Daemen T, Roerdink FH. Scherphof GL, et al. Biochem Soc Trans. 1987 Jun;15(3):345-8. doi: 10.1042/bst0150345. Biochem Soc Trans. 1987. PMID: 3622912 No abstract available.