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Did you mean ke xin chen (56 results)?
Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway.
Deng S, Dai G, Chen S, Nie Z, Zhou J, Fang H, Peng H. Deng S, et al. Biomed Pharmacother. 2019 Feb;110:602-608. doi: 10.1016/j.biopha.2018.11.103. Epub 2018 Dec 8. Biomed Pharmacother. 2019. PMID: 30537677 Free article.
Then the effects of GSK3beta knockdown on Dex-induced apoptosis of osteoblasts were explored. Alkaline phosphatase (ALP) activity assay was used to detect the role of Dex in regulating ALP activity. ...Dex potentially attenuated the osteoblast differentiation …
Then the effects of GSK3beta knockdown on Dex-induced apoptosis of osteoblasts were explored. Alkaline phosphatase (ALP) activity ass …
Research progress of therapeutic drugs for doxorubicin-induced cardiomyopathy.
Chen Y, Shi S, Dai Y. Chen Y, et al. Biomed Pharmacother. 2022 Dec;156:113903. doi: 10.1016/j.biopha.2022.113903. Epub 2022 Oct 21. Biomed Pharmacother. 2022. PMID: 36279722 Free article. Review.
DOX-induced cardiomyopathy is not a result of a single mechanistic action, and multiple mechanisms have been discovered and demonstrated experimentally, such as oxidative stress, inflammation, mitochondrial damage, calcium homeostasis disorder, ferroptosis, autophagy and apoptosi …
DOX-induced cardiomyopathy is not a result of a single mechanistic action, and multiple mechanisms have been discovered and demonstrated exp …
Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates.
Meng QF, Tai W, Tian M, Zhuang X, Pan Y, Lai J, Xu Y, Xu Z, Li M, Zhao G, Yu GT, Yu G, Chen R, Jin N, Li X, Cheng G, Chen X, Rao L. Meng QF, et al. Sci Adv. 2023 Jun 16;9(24):eadg3277. doi: 10.1126/sciadv.adg3277. Epub 2023 Jun 14. Sci Adv. 2023. PMID: 37315135 Free PMC article.
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse effects. ...The nanoDEX, made by encapsulating DEX with the iSEND, efficiently promote …
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while …
Ca-DEX biomineralization-inducing nuts reverse oxidative stress and bone loss in rheumatoid arthritis.
Liu Y, Wang Z, Wang Y, Feng Y, Xu M, Ma X, Shi Q, Deng H, Ren F, Chen Y, Chen H. Liu Y, et al. Nanoscale. 2023 Aug 25;15(33):13822-13833. doi: 10.1039/d3nr01324c. Nanoscale. 2023. PMID: 37578313
Herein, we propose a Ca-DEX biomineralization-inducing nut (CaCO(3)-DEX) with controlled release properties for mitigating the toxic side effects of DEX in RA treatment, especially the damage to cartilage and bone. CaCO(3)-DEX releases the drug and Ca( …
Herein, we propose a Ca-DEX biomineralization-inducing nut (CaCO(3)-DEX) with controlled release properties for mitigating the …
Dexmedetomidine Pretreatment Protects Against Myocardial Ischemia/Reperfusion Injury by Activating STAT3 Signaling.
Chen ZR, Hong Y, Wen SH, Zhan YQ, Huang WQ. Chen ZR, et al. Anesth Analg. 2023 Aug 1;137(2):426-439. doi: 10.1213/ANE.0000000000006487. Epub 2023 May 5. Anesth Analg. 2023. PMID: 37145970 Free PMC article.
In vitro, hypoxia/reoxygenation (H/R) with DEX pretreatment for 1 hour was performed in isolated neonatal rat cardiomyocytes. ...CONCLUSIONS: DEX pretreatment protects against myocardial IRI, presumably by promoting STAT3 phosphorylation via the alpha2-adrenorecepto …
In vitro, hypoxia/reoxygenation (H/R) with DEX pretreatment for 1 hour was performed in isolated neonatal rat cardiomyocytes. ...CONC …
Neutrophil elastase in dexmedetomidine alleviating sepsis-related renal injury in rats.
Chen L, Li M, Lin Y, Li Y, Liang M, Zeng K. Chen L, et al. Int Immunopharmacol. 2023 Sep;122:110441. doi: 10.1016/j.intimp.2023.110441. Epub 2023 Jun 30. Int Immunopharmacol. 2023. PMID: 37393835
BACKGROUND: This research was to investigate the mechanism of neutrophil elastase (NE) in dexmedetomidine (DEX) alleviates sepsis-related renal injury in rats. METHODS: Sixty healthy male SD rats aged 6-7 weeks were randomly assigned to the control group (Sham group (S gro …
BACKGROUND: This research was to investigate the mechanism of neutrophil elastase (NE) in dexmedetomidine (DEX) alleviates sepsis-rel …
Intravitreal dexamethasone implants facilitate the management of refractory Behçet's uveitis with vasculitis.
Tao T, Yang S, He D, Li Z, Chen B, Zhu L, Su W. Tao T, et al. Clin Immunol. 2023 Jun;251:109633. doi: 10.1016/j.clim.2023.109633. Epub 2023 May 5. Clin Immunol. 2023. PMID: 37150241 Free article.
To investigate the efficacy and safety of dexamethasone (DEX) implant, Ozurdex , as an adjunctive treatment for refractory Behcet's uveitis (BU), a total of 61 patients (80 eyes) were included in this cross-sectional study and divided into the non-DEX and DEX …
To investigate the efficacy and safety of dexamethasone (DEX) implant, Ozurdex , as an adjunctive treatment for refractory Behcet's u …
Anti-angiogenic and anti-multiple myeloma effects of oprozomib (OPZ) alone and in combination with pomalidomide (Pom) and/or dexamethasone (Dex).
Sanchez E, Li M, Wang CS, Tang G, Gillespie A, Chen H, Berenson JR. Sanchez E, et al. Leuk Res. 2017 Jun;57:45-54. doi: 10.1016/j.leukres.2017.03.002. Epub 2017 Mar 6. Leuk Res. 2017. PMID: 28288323 Review.
In vivo, we determined the anti-MM effects of OPZ, dexamethasone (Dex) and pomalidomide (Pom) and showed that the combinations of two drugs (OPZ+Dex or OPZ+Pom) showed marked anti-MM effects when compared to monotherapy. Pom+Dex and the triplicate combination …
In vivo, we determined the anti-MM effects of OPZ, dexamethasone (Dex) and pomalidomide (Pom) and showed that the combinations of two …
Dexamethasone Liposomes Alleviate Osteoarthritis in miR-204/-211-Deficient Mice by Repolarizing Synovial Macrophages to M2 Phenotypes.
Teng H, Chen S, Fan K, Wang Q, Xu B, Chen D, Zhao F, Wang T. Teng H, et al. Mol Pharm. 2023 Aug 7;20(8):3843-3853. doi: 10.1021/acs.molpharmaceut.2c00979. Epub 2023 Jul 12. Mol Pharm. 2023. PMID: 37437059
Dex-Lips was prepared by the thin-film hydration method. The characterization of Dex-Lips was identified by the mean size, zeta potential, drug loading, and encapsulation efficiencies. ...Dex-Lips could attenuate pain by regulating PGE2. Dex-Lips treat …
Dex-Lips was prepared by the thin-film hydration method. The characterization of Dex-Lips was identified by the mean size, zet …
Effects of Dexmedetomidine on Immune Cells: A Narrative Review.
Chen R, Sun Y, Lv J, Dou X, Dai M, Sun S, Lin Y. Chen R, et al. Front Pharmacol. 2022 May 2;13:829951. doi: 10.3389/fphar.2022.829951. eCollection 2022. Front Pharmacol. 2022. PMID: 35586059 Free PMC article. Review.
At present, there have been more and more studies on the effects of DEX on immune cells and inflammatory responses, but few studies have systematically explored the anti-inflammatory and immunomodulatory effects of DEX. Here, we comprehensively review the published …
At present, there have been more and more studies on the effects of DEX on immune cells and inflammatory responses, but few studies h …
970 results