Effects of Dexmedetomidine on Immune Cells: A Narrative Review

Rui Chen; Yan Sun; Jing Lv; Xiaoke Dou; Maosha Dai; Shujun Sun; Yun Lin

doi:10.3389/fphar.2022.829951

Effects of Dexmedetomidine on Immune Cells: A Narrative Review

Front Pharmacol. 2022 May 2:13:829951. doi: 10.3389/fphar.2022.829951. eCollection 2022.

Authors

Rui Chen^{1

2}, Yan Sun^{1

2}, Jing Lv^{1

2}, Xiaoke Dou^{1

2}, Maosha Dai^{1

2}, Shujun Sun^{1

2}, Yun Lin^{1

2}

Affiliations

¹ Institute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

As we all know, dexmedetomidine (DEX), as a highly selective α₂ adrenergic receptor agonist, exerts sedative, anti-anxiety and hypnotic effects by inhibiting the discharge of norepinephrine neurons in locus coeruleus and GABA-related hypnotic pathways. However, the role of DEX in anti-inflammatory and immune regulation has gradually attracted the attention of researchers in recent years. The α₂ adrenergic receptor is one of the members of the adrenergic receptor family, which is widely present in a variety of immune cells and mediates the biological behavior of the inflammatory immune system. At present, there have been more and more studies on the effects of DEX on immune cells and inflammatory responses, but few studies have systematically explored the anti-inflammatory and immunomodulatory effects of DEX. Here, we comprehensively review the published human and animal studies related to DEX, summarize the effects of DEX on immune cells and its role in related diseases, and propose potential research direction.

Keywords: adaptive immune response; dexmedetomidine; immune cells; inflammatory factors; innate immune response.

Publication types

Review