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rac-Ethyl rel-(2R,3R,4S)-4-hy-droxy-1,2-dimethyl-5-oxopyrrolidine-3-carboxyl-ate.
Abdul Rashid FNA, Bacho MZ, Hamali MA, Slawin AMZ, Mohammat MF, Shamsujunaidi R, Abdul Manan MAF. Abdul Rashid FNA, et al. IUCrdata. 2023 Feb 9;8(Pt 2):x230075. doi: 10.1107/S2414314623000755. eCollection 2023 Feb. IUCrdata. 2023. PMID: 36911075 Free PMC article.
The asymmetric unit of the title compound, C(9)H(15)NO(4), consists of a functionalized pyrrolidine ring having an envelope conformation, synthesized as an ethyl ester. The mol-ecule has three chiral centres and crystallized as a racemic mixture. In the crystal, mol-ecules …
The asymmetric unit of the title compound, C(9)H(15)NO(4), consists of a functionalized pyrrolidine ring having an envelope conformation, sy …
Chiral pesticides: identification, description, and environmental implications.
Ulrich EM, Morrison CN, Goldsmith MR, Foreman WT. Ulrich EM, et al. Rev Environ Contam Toxicol. 2012;217:1-74. doi: 10.1007/978-1-4614-2329-4_1. Rev Environ Contam Toxicol. 2012. PMID: 22350557 Review.
Of the chiral pesticides, 270 (56%) have one chiral feature, 105 (22%) have two chiral features, 30 (6.2%) have three chiral features, and 29 (6.0%) have ten or more chiral features.Chiral chemicals pose many difficulties in stereospecifi …
Of the chiral pesticides, 270 (56%) have one chiral feature, 105 (22%) have two chiral features, 30 (6.2%) have three …
Chiral fungicide penconazole: Absolute configuration, bioactivity, toxicity, and stereoselective degradation in apples.
Li Y, Nie J, Zhang J, Xu G, Zhang H, Liu M, Gao X, Shah BSA, Yin N. Li Y, et al. Sci Total Environ. 2022 Feb 20;808:152061. doi: 10.1016/j.scitotenv.2021.152061. Epub 2021 Nov 30. Sci Total Environ. 2022. PMID: 34861299 Review.
Traditional evaluation of chiral pesticides can lead to inaccurate results, as their enantiomers may show different properties. Penconazole, a chiral triazole fungicide with two enantiomers, is widely applied to protect against phytopathogens. ...
Traditional evaluation of chiral pesticides can lead to inaccurate results, as their enantiomers may show different properties. Penco …
Drug Stereochemistry: A Prodigy For Pharmacology and Drug Development.
Gandhi K, Shah U, Patel S. Gandhi K, et al. Curr Drug Discov Technol. 2020;17(5):565-573. doi: 10.2174/1570163816666190502101803. Curr Drug Discov Technol. 2020. PMID: 31057115 Review.
Stereochemistry has evinced the importance of many chiral drugs with respect to drug designing and development. A literature review was conducted for several chiral drugs involving pharmacokinetic and pharmacodynamic parameters of their enantiomers along with their …
Stereochemistry has evinced the importance of many chiral drugs with respect to drug designing and development. A literature review w …
Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines.
Chamakuri S, Shah MM, Yang DCH, Santini C, Young DW. Chamakuri S, et al. Org Biomol Chem. 2020 Nov 12;18(43):8844-8849. doi: 10.1039/d0ob01713b. Org Biomol Chem. 2020. PMID: 33118584
A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from alpha-amino acids, within four steps chiral 2-substituted piperazines are obtained. The key transformation involves an aza-Michael addition between an o …
A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from alpha-amino acids, …
Peptoid atropisomers.
Paul B, Butterfoss GL, Boswell MG, Renfrew PD, Yeung FG, Shah NH, Wolf C, Bonneau R, Kirshenbaum K. Paul B, et al. J Am Chem Soc. 2011 Jul 20;133(28):10910-9. doi: 10.1021/ja2028684. Epub 2011 Jun 22. J Am Chem Soc. 2011. PMID: 21634437
We report the isolation of N-aryl peptoid oligomers that adopt chiral folds, despite the absence of chiral centers. Peptoid monomers incorporating ortho-substituted N-aryl side chains are identified that exhibit axial chirality. ...
We report the isolation of N-aryl peptoid oligomers that adopt chiral folds, despite the absence of chiral centers. Peptoid mo …
Synthesis of Chiral 2,3-Dihydrofurans via One-Pot Pd-Catalyzed Asymmetric Allylic Cycloaddition and a Retro-Dieckmann Fragmentation Cascade.
Shah BH, Khan S, Zhao C, Zhang YJ. Shah BH, et al. J Org Chem. 2023 Aug 18;88(16):12100-12104. doi: 10.1021/acs.joc.3c00976. Epub 2023 Aug 8. J Org Chem. 2023. PMID: 37552623
The asymmetric allylic cycloaddition of vinylethylene carbonates with 3-cyanochromone followed by base-assisted retro-Dieckmann fragmentation proceeded smoothly via a one-pot process to produce chiral 3,4-disubstituted 2,3-dihydrofurans in high yields with excellent enanti …
The asymmetric allylic cycloaddition of vinylethylene carbonates with 3-cyanochromone followed by base-assisted retro-Dieckmann fragmentatio …
Absolute Configuration Determination of Chiral API Molecules by MicroED Analysis of Cocrystal Powders Formed Based on Cocrystal Propensity Prediction Calculations.
Shah HS, Yuan J, Xie T, Yang Z, Chang C, Greenwell C, Zeng Q, Sun G, Read BN, Wilson TS, Valle HU, Kuang S, Wang J, Sekharan S, Bruhn JF. Shah HS, et al. Chemistry. 2023 Mar 7;29(14):e202203970. doi: 10.1002/chem.202203970. Epub 2023 Feb 6. Chemistry. 2023. PMID: 36744589 Free PMC article.
Establishing the absolute configuration of chiral active pharmaceutical ingredients (APIs) is of great importance. ...Here, we present a method for determining absolute configuration that does not rely on the growth of large crystals. By examining microcrystals formed with …
Establishing the absolute configuration of chiral active pharmaceutical ingredients (APIs) is of great importance. ...Here, we presen …
Enantioselective chromatography-a powerful tool for the discrimination of biotic and abiotic transformation processes of chiral environmental pollutants.
Hühnerfuss H, Shah MR. Hühnerfuss H, et al. J Chromatogr A. 2009 Jan 16;1216(3):481-502. doi: 10.1016/j.chroma.2008.09.043. Epub 2008 Sep 17. J Chromatogr A. 2009. PMID: 18838139 Review.
On the basis of the general principles of chirality the characteristics of chromatograms obtained by enantioselective GC and HPLC are explained, followed by a description of different enantioselective chromatographic methods (HPLC, high-resolution GC, multidimensional GC, …
On the basis of the general principles of chirality the characteristics of chromatograms obtained by enantioselective GC and HPLC are …
61 results