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1999 1
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15 results

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Page 1
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection.
GlobalSurg Collaborative. GlobalSurg Collaborative. BJS Open. 2019 Feb 28;3(3):403-414. doi: 10.1002/bjs5.50138. eCollection 2019 Jun. BJS Open. 2019. PMID: 31891112 Free PMC article.

The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3.20, 95 per cent c.i. 1.35 to 7.57; P = 0.008) after risk adjustment for malignant disease (OR 2.34, 1.65 to 3.32; P < 0.001), emergency surgery (OR 4.08, 2.73 to 6.10; P < 0.001), time to op

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The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3.20, 95 per cent c.i. 1.35 to 7.57; P = 0.008) after risk …
Controlling Doxorubicin Release from a Peptide Hydrogel through Fine-Tuning of Drug-Peptide Fiber Interactions.
Elsawy MA, Wychowaniec JK, Castillo Díaz LA, Smith AM, Miller AF, Saiani A. Elsawy MA, et al. Biomacromolecules. 2022 Jun 13;23(6):2624-2634. doi: 10.1021/acs.biomac.2c00356. Epub 2022 May 11. Biomacromolecules. 2022. PMID: 35543610 Free PMC article.
In the drug delivery field, in particular, they have been the subject of significant interest for the spatially and temporally controlled delivery of anticancer drugs and therapeutics. Self-assembling peptide-based hydrogels, in particular, have recently come to the fore a …
In the drug delivery field, in particular, they have been the subject of significant interest for the spatially and temporally controlled de …
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide.
Al-Zuhairy SAS, Teaima MH, Shoman NA, Elasaly M, El-Nabarawi MA, El-Sawy HS. Al-Zuhairy SAS, et al. Drug Deliv. 2023 Dec;30(1):2189112. doi: 10.1080/10717544.2023.2189112. Drug Deliv. 2023. PMID: 36916128 Free PMC article.
It was also revealed that the intranasal dual-optimized ISG significantly had the lowest liver-AUC(0-) (862.19 ng.g(-1).h(-1)) versus the MTC-oral tablet (5732.17 ng.g(-1).h(-1)) and the intranasal raw MTC-loaded ISG (1799.69 ng.g(-1).h(-1)). ...
It was also revealed that the intranasal dual-optimized ISG significantly had the lowest liver-AUC(0-) (862.19 ng.g(-1).h(-1)) versus …
Expansion of Peripheral Visual Field with Novel Virtual Reality Digital Spectacles.
Sayed AM, Abdel-Mottaleb M, Kashem R, Roongpoovapatr V, Elsawy A, Abdel-Mottaleb M, Parrish RK 2nd, Abou Shousha M. Sayed AM, et al. Am J Ophthalmol. 2020 Feb;210:125-135. doi: 10.1016/j.ajo.2019.10.006. Epub 2019 Oct 15. Am J Ophthalmol. 2020. PMID: 31626763 Free PMC article.
RESULTS: The diagnostic monocular VF testing algorithm was comparable to standard automated perimetric determination of threshold sensitivity based on point-by-point assessment. Eighteen of 23 patients (78%) could identify safety hazards with the DSpecs that they could not …
RESULTS: The diagnostic monocular VF testing algorithm was comparable to standard automated perimetric determination of threshold sensitivit …
Disruption of 3CLpro protease self-association by short peptides as a potential route to broad spectrum coronavirus inhibitors.
ElSawy KM, Alminderej FM, Caves LSD. ElSawy KM, et al. J Biomol Struct Dyn. 2022;40(24):13901-13911. doi: 10.1080/07391102.2021.1996462. Epub 2021 Nov 1. J Biomol Struct Dyn. 2022. PMID: 34720051
Here, we assess the potential of short peptide segments to disrupt dimerization of the 3CLpro protease as a route to block COVID-19 proliferation. Based on the X-ray structure of the 3CLpro dimer, we identified the SPSGVY(126)QCAMRP dodecapeptide segment as overlapping the …
Here, we assess the potential of short peptide segments to disrupt dimerization of the 3CLpro protease as a route to block COVID-19 prolifer …
Oleic acid-reinforced PEGylated polymethacrylate transdermal film with enhanced antidyslipidemic activity and bioavailability of atorvastatin: A mechanistic ex-vivo/in-vivo analysis.
El-Say KM, Ahmed TA, Aljefri AH, El-Sawy HS, Fassihi R, Abou-Gharbia M. El-Say KM, et al. Int J Pharm. 2021 Oct 25;608:121057. doi: 10.1016/j.ijpharm.2021.121057. Epub 2021 Aug 28. Int J Pharm. 2021. PMID: 34461173
Steady-state flux was 0.172 mg/cm(2)h, with 7.01 10(-4) cm/h permeability coefficient, and 0.713 10(-3) cm(2)/h diffusion coefficient. ...PD assessment of the lipid panel indicated that the lipid profile of the optimized film pre-treated group reached normal …
Steady-state flux was 0.172 mg/cm(2)h, with 7.01 10(-4) cm/h permeability coefficient, and 0.713 10(-3) cm(2)/h diffusi …
Synthesis, Anticancer, Antioxidant, Anti-Inflammatory, Antimicrobial Activities, Molecular Docking, and DFT Studies of Sultams Derived from Saccharin.
Al-Fayez N, Elsawy H, Mansour MA, Akbar Ali M, Elghamry I. Al-Fayez N, et al. Molecules. 2022 Oct 20;27(20):7104. doi: 10.3390/molecules27207104. Molecules. 2022. PMID: 36296696 Free PMC article.
A series of N-substituted saccharins namely 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetonitrile (2) and (alkyl 1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetate (3a-g) were synthesized, in moderate to excellent yields, from commercially available starting materials …
A series of N-substituted saccharins namely 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetonitrile (2) and (alkyl 1,1-dioxido-3-oxobe …
Radiation fabrication of Xanthan-based wound dressing hydrogels embedded ZnO nanoparticles: In vitro evaluation.
Raafat AI, El-Sawy NM, Badawy NA, Mousa EA, Mohamed AM. Raafat AI, et al. Int J Biol Macromol. 2018 Oct 15;118(Pt B):1892-1902. doi: 10.1016/j.ijbiomac.2018.07.031. Epub 2018 Jul 12. Int J Biol Macromol. 2018. PMID: 30017987
The fluid uptake ability in pseudo-extracellular fluid and water ranged between (554-664%) and (1281-1603%), respectively. After exposure to air for 6 h, ZnO dressings kept about 50-65% of their water content which makes them more suitable for moderate exudating wounds. Wa …
The fluid uptake ability in pseudo-extracellular fluid and water ranged between (554-664%) and (1281-1603%), respectively. After exposure to …
Mechanistic effects of blending formic acid with ethanol on Pd activity towards formic acid oxidation in acidic media.
Al Najjar T, Ahmed N, El Sawy EN. Al Najjar T, et al. RSC Adv. 2021 Jun 29;11(37):22842-22848. doi: 10.1039/d1ra01209f. eCollection 2021 Jun 25. RSC Adv. 2021. PMID: 35480453 Free PMC article.
The catalytic activity of a 40% Pd/C catalyst was tested in 0.1 M H(2)SO(4) + XFA + YEtOH using cyclic voltammetry, while the catalyst resistance to poisoning in the presence and absence of ethanol was tested using chronopotentiometry. ...This study should open the door fo …
The catalytic activity of a 40% Pd/C catalyst was tested in 0.1 M H(2)SO(4) + XFA + YEtOH using cyclic voltammetry, while the catalys …
Human retroelements may introduce intragenic polyadenylation signals.
Roy-Engel AM, El-Sawy M, Farooq L, Odom GL, Perepelitsa-Belancio V, Bruch H, Oyeniran OO, Deininger PL. Roy-Engel AM, et al. Cytogenet Genome Res. 2005;110(1-4):365-71. doi: 10.1159/000084968. Cytogenet Genome Res. 2005. PMID: 16093688
Computational analysis of 34 genes randomly retrieved from the human genome draft sequence reveals an orientation bias, reflected as a lower number of L1s and Alus containing the pA in the same orientation as the gene. Experimental studies of Alu-based pA sequences when pl …
Computational analysis of 34 genes randomly retrieved from the human genome draft sequence reveals an orientation bias, reflected as a lower …
15 results