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Temporal-iCLIP captures co-transcriptional RNA-protein interactions.
Cordiner RA, Dou Y, Thomsen R, Bugai A, Granneman S, Heick Jensen T. Cordiner RA, et al. Nat Commun. 2023 Feb 8;14(1):696. doi: 10.1038/s41467-023-36345-y. Nat Commun. 2023. PMID: 36755023 Free PMC article.
Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA polymerase II (RNAPII)-derived transcripts. Yet, our current understanding of this process in vivo primarily stems from steady state analysis. ...
Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA polymerase II (RNAPII)-derived transcripts. Yet, our …
ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts.
Rouvière JO, Salerno-Kochan A, Lykke-Andersen S, Garland W, Dou Y, Rathore O, Molska EŠ, Wu G, Schmid M, Bugai A, Jakobsen L, Žumer K, Cramer P, Andersen JS, Conti E, Jensen TH. Rouvière JO, et al. Mol Cell. 2023 Jul 6;83(13):2240-2257.e6. doi: 10.1016/j.molcel.2023.05.028. Epub 2023 Jun 16. Mol Cell. 2023. PMID: 37329882
The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II (RNAPII) transcription termination and transcript decay. Despite its essential nature, the mechanisms by which ARS2 enacts these functions have remained unclear. ...
The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II (RNAPII) transcription termination and transcript …
Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb.
C Quaresma AJ, Bugai A, Barboric M. C Quaresma AJ, et al. Nucleic Acids Res. 2016 Sep 19;44(16):7527-39. doi: 10.1093/nar/gkw585. Epub 2016 Jul 1. Nucleic Acids Res. 2016. PMID: 27369380 Free PMC article. Review.
Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a critical step regulating gene expression in multicellular organisms. ...Here, we provide an overview on stimulating Pol II pause release by P-TEFb and on sequestering P-TEFb …
Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a critical step regulating gene expression …
Activation of P-TEFb by RBM7: To Live or Let Die.
Le May N, Coin F. Le May N, et al. Mol Cell. 2019 Apr 18;74(2):223-224. doi: 10.1016/j.molcel.2019.03.039. Mol Cell. 2019. PMID: 31002802 Free article.
In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic attack is the activation of P-TEFb by RBM7. This crucial step triggers RNA polymerase II release from promoter-proximal pausing and expre …
In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic atta …
P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.
Bugai A, Quaresma AJC, Friedel CC, Lenasi T, Düster R, Sibley CR, Fujinaga K, Kukanja P, Hennig T, Blasius M, Geyer M, Ule J, Dölken L, Barborič M. Bugai A, et al. Mol Cell. 2019 Apr 18;74(2):254-267.e10. doi: 10.1016/j.molcel.2019.01.033. Epub 2019 Feb 26. Mol Cell. 2019. PMID: 30824372 Free PMC article.
Here, we show that following genotoxic stress, the RNA-binding motif protein 7 (RBM7) stimulates RNA polymerase II (Pol II) transcription and promotes cell viability by activating the positive transcription elongation factor b (P-TEFb) via its release from the inhib …
Here, we show that following genotoxic stress, the RNA-binding motif protein 7 (RBM7) stimulates RNA polymerase II (Pol II) tr …
P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway.
Wang Z, Mačáková M, Bugai A, Kuznetsov SG, Hassinen A, Lenasi T, Potdar S, Friedel CC, Barborič M. Wang Z, et al. Nucleic Acids Res. 2023 Feb 28;51(4):1687-1706. doi: 10.1093/nar/gkad001. Nucleic Acids Res. 2023. PMID: 36727434 Free PMC article.
Positive transcription elongation factor b (P-TEFb) is the crucial player in RNA polymerase II (Pol II) pause release that has emerged as a promising target in cancer. ...
Positive transcription elongation factor b (P-TEFb) is the crucial player in RNA polymerase II (Pol II) pause release that has …