Activation of P-TEFb by RBM7: To Live or Let Die

Nicolas Le May; Frédéric Coin

doi:10.1016/j.molcel.2019.03.039

Activation of P-TEFb by RBM7: To Live or Let Die

Mol Cell. 2019 Apr 18;74(2):223-224. doi: 10.1016/j.molcel.2019.03.039.

Authors

Nicolas Le May¹, Frédéric Coin²

Affiliations

¹ IGBMC (CNRS, INSERM, UdS), 1 rue Laurent Fries, 67400 Illkirch Graffenstaden, France.
² IGBMC (CNRS, INSERM, UdS), 1 rue Laurent Fries, 67400 Illkirch Graffenstaden, France. Electronic address: fredr@igbmc.fr.

PMID: 31002802
DOI: 10.1016/j.molcel.2019.03.039

Abstract

In this issue of Molecular Cell, Bugai et al. (2019) unveil that a key step of the pro-survival cellular response to a genotoxic attack is the activation of P-TEFb by RBM7. This crucial step triggers RNA polymerase II release from promoter-proximal pausing and expression of DNA damage response genes.

Publication types

Comment

MeSH terms

DNA Damage
Positive Transcriptional Elongation Factor B*
Promoter Regions, Genetic
RNA Polymerase II*

Substances

Positive Transcriptional Elongation Factor B
RNA Polymerase II