A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.
Cal K, Leyva A, Rodríguez-Duarte J, Ruiz S, Santos L, Colella L, Ingold M, Vilaseca C, Galliussi G, Ziegler L, Peclat TR, Bresque M, Handy RM, King R, Dos Reis LM, Espasandin C, Breining P, Dapueto R, Lopez A, Thompson KL, Agorrody G, DeVallance E, Meadows E, Lewis SE, Barbosa GCS, de Souza LOL, Chichierchio MS, Valez V, Aicardo A, Contreras P, Vendelbo MH, Jakobsen S, Kamaid A, Porcal W, Calliari A, Verdes JM, Du J, Wang Y, Hollander JM, White TA, Radi R, Moyna G, Quijano C, O'Doherty R, Moraes-Vieira P, Holloway GP, Leonardi R, Mori MA, Camacho-Pereira J, Kelley EE, Duran R, Lopez GV, Batthyány C, Chini EN, Escande C.
Cal K, et al.
Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-3101395. doi: 10.21203/rs.3.rs-3101395/v1.
Res Sq. 2023.
PMID: 37502859
Free PMC article.
Preprint.
SANA reduces DIO, liver steatosis and insulin resistance at doses up to 40 times lower than salicylate. ...Indeed, depletion of creatine resulted in the loss of SANA action. Moreover, we found that SANA binds to creatine kinases CKMT1/2, and downregulation CK …
SANA reduces DIO, liver steatosis and insulin resistance at doses up to 40 times lower than salicylate. ...Indeed, depletion of creat …