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Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker.
Duvall B, Zimmermann SC, Gao RD, Thomas AG, Kalčic F, Veeravalli V, Elgogary A, Rais R, Rojas C, Le A, Slusher BS, Tsukamoto T. Duvall B, et al. Among authors: zimmermann sc. Bioorg Med Chem. 2020 Oct 15;28(20):115698. doi: 10.1016/j.bmc.2020.115698. Epub 2020 Aug 6. Bioorg Med Chem. 2020. PMID: 33069080 Free PMC article.
Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines.
Temburnikar KW, Zimmermann SC, Kim NT, Ross CR, Gelbmann C, Salomon CE, Wilson GM, Balzarini J, Seley-Radtke KL. Temburnikar KW, et al. Among authors: zimmermann sc. Bioorg Med Chem. 2014 Apr 1;22(7):2113-22. doi: 10.1016/j.bmc.2014.02.033. Epub 2014 Mar 3. Bioorg Med Chem. 2014. PMID: 24631358 Free PMC article.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.
Nedelcovych M, Dash RP, Tenora L, Zimmermann SC, Gadiano AJ, Garrett C, Alt J, Hollinger KR, Pommier E, Jančařík A, Rojas C, Thomas AG, Wu Y, Wozniak K, Majer P, Slusher BS, Rais R. Nedelcovych M, et al. Among authors: zimmermann sc. Mol Pharm. 2017 Oct 2;14(10):3248-3257. doi: 10.1021/acs.molpharmaceut.7b00231. Epub 2017 Aug 31. Mol Pharm. 2017. PMID: 28763226 Free PMC article.
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS. Rojas C, et al. Among authors: zimmermann sc. Sci Rep. 2018 Dec 7;8(1):17715. doi: 10.1038/s41598-018-36144-2. Sci Rep. 2018. PMID: 30531925 Free PMC article.
18 results