Abstract
Several thieno-expanded purine nucleoside analogues were synthesized for use as tools in ongoing investigations into nucleic acid structure and function in our laboratories. The inclusion of the thiophene ring system in the nucleoside endows the purine scaffold with advantages not previously available in other reported expanded purines. The synthesis and preliminary biological studies are reported herein.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Drug Design
-
Enzyme Inhibitors / chemical synthesis*
-
Enzyme Inhibitors / chemistry
-
Enzyme Inhibitors / pharmacology
-
Purine Nucleosides / chemical synthesis*
-
Purine Nucleosides / chemistry
-
Purine Nucleosides / pharmacology*
-
RNA-Dependent RNA Polymerase / antagonists & inhibitors*
-
RNA-Dependent RNA Polymerase / metabolism
Substances
-
Enzyme Inhibitors
-
Purine Nucleosides
-
RNA-Dependent RNA Polymerase