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The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5.
Shuai H, Chan JF, Hu B, Chai Y, Yoon C, Liu H, Liu Y, Shi J, Zhu T, Hu JC, Hu YF, Hou Y, Huang X, Yuen TT, Wang Y, Zhang J, Xia Y, Chen LL, Cai JP, Zhang AJ, Yuan S, Zhou J, Zhang BZ, Huang JD, Yuen KY, To KK, Chu H. Shuai H, et al. Among authors: chen ll. EBioMedicine. 2023 Sep;95:104753. doi: 10.1016/j.ebiom.2023.104753. Epub 2023 Aug 12. EBioMedicine. 2023. PMID: 37579626 Free PMC article.
Rational design of a booster vaccine against COVID-19 based on antigenic distance.
Hu YF, Yuen TT, Gong HR, Hu B, Hu JC, Lin XS, Rong L, Zhou CL, Chen LL, Wang X, Lei C, Yau T, Hung IF, To KK, Yuen KY, Zhang BZ, Chu H, Huang JD. Hu YF, et al. Among authors: chen ll. Cell Host Microbe. 2023 Aug 9;31(8):1301-1316.e8. doi: 10.1016/j.chom.2023.07.004. Epub 2023 Jul 31. Cell Host Microbe. 2023. PMID: 37527659 Free article.
Broad-spectrum humanized monoclonal neutralizing antibody against SARS-CoV-2 variants, including the Omicron variant.
Wen K, Cai JP, Fan X, Zhang X, Luo C, Tang KM, Shuai H, Chen LL, Zhang RR, Situ J, Tsoi HW, Wang K, Chan JF, Yuan S, Yuen KY, Zhou H, To KK. Wen K, et al. Among authors: chen ll. Front Cell Infect Microbiol. 2023 Aug 14;13:1213806. doi: 10.3389/fcimb.2023.1213806. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37645378 Free PMC article.
Serum neutralisation of the SARS-CoV-2 omicron sublineage BA.2.
Chen LL, Chu AW, Zhang RR, Hung IF, To KK. Chen LL, et al. Lancet Microbe. 2022 Jun;3(6):e404. doi: 10.1016/S2666-5247(22)00060-X. Epub 2022 Mar 28. Lancet Microbe. 2022. PMID: 35373159 Free PMC article. No abstract available.
Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice.
Cai JP, Luo C, Wang K, Cao H, Chen LL, Zhang X, Han Y, Yin F, Zhang AJ, Chu H, Yuan S, Kok KH, To KK, Chen H, Chen Z, Jin DY, Yuen KY, Chan JF. Cai JP, et al. Among authors: chen ll. Viruses. 2023 Mar 6;15(3):687. doi: 10.3390/v15030687. Viruses. 2023. PMID: 36992395 Free PMC article.
Effect of vaccine booster, vaccine type, and hybrid immunity on humoral and cellular immunity against SARS-CoV-2 ancestral strain and Omicron variant sublineages BA.2 and BA.5 among older adults with comorbidities: a cross sectional study.
Fong CH, Zhang X, Chen LL, Poon RW, Chan BP, Zhao Y, Wong CK, Chan KH, Yuen KY, Hung IF, Yuen JKY, To KK. Fong CH, et al. Among authors: chen ll. EBioMedicine. 2023 Feb;88:104446. doi: 10.1016/j.ebiom.2023.104446. Epub 2023 Jan 25. EBioMedicine. 2023. PMID: 36706582 Free PMC article.
46 results