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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2013 4
2014 5
2015 8
2016 11
2017 8
2018 6
2019 11
2020 6
2021 9
2022 3
2023 2
2024 0

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65 results

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Page 1
Will morphing boron-based inhibitors beat the β-lactamases?
Krajnc A, Lang PA, Panduwawala TD, Brem J, Schofield CJ. Krajnc A, et al. Among authors: brem j. Curr Opin Chem Biol. 2019 Jun;50:101-110. doi: 10.1016/j.cbpa.2019.03.001. Epub 2019 Apr 18. Curr Opin Chem Biol. 2019. PMID: 31004962 Free PMC article. Review.
The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.
Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ. Pettinati I, et al. Among authors: brem j. Trends Biochem Sci. 2016 Apr;41(4):338-355. doi: 10.1016/j.tibs.2015.12.007. Epub 2016 Jan 21. Trends Biochem Sci. 2016. PMID: 26805042 Free PMC article. Review.
Profiling interactions of vaborbactam with metallo-β-lactamases.
Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J. Langley GW, et al. Among authors: brem j. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17. Bioorg Med Chem Lett. 2019. PMID: 31171422 Free PMC article.
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.
Krajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA, Kamps JJAG, Tyrrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ. Krajnc A, et al. Among authors: brem j. J Med Chem. 2019 Sep 26;62(18):8544-8556. doi: 10.1021/acs.jmedchem.9b00911. Epub 2019 Sep 16. J Med Chem. 2019. PMID: 31454231 Free PMC article.
Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.
Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI. Abboud MI, et al. Among authors: brem j. Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17. Chemistry. 2018. PMID: 29250863 Free PMC article.
Use of ferrous iron by metallo-β-lactamases.
Cahill ST, Tarhonskaya H, Rydzik AM, Flashman E, McDonough MA, Schofield CJ, Brem J. Cahill ST, et al. Among authors: brem j. J Inorg Biochem. 2016 Oct;163:185-193. doi: 10.1016/j.jinorgbio.2016.07.013. Epub 2016 Jul 26. J Inorg Biochem. 2016. PMID: 27498591 Free PMC article.
65 results