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Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation.
Front Pharmacol. 2023 Dec 19;14:1287487. doi: 10.3389/fphar.2023.1287487. eCollection 2023.
Front Pharmacol. 2023.
PMID: 38178859
Free PMC article.
Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema.
Davie RL, Edwards HJ, Evans DM, Hodgson ST, Stocks MJ, Smith AJ, Rushbrooke LJ, Pethen SJ, Roe MB, Clark DE, McEwan PA, Hampton SL.
Davie RL, et al. Among authors: edwards hj.
J Med Chem. 2022 Oct 27;65(20):13629-13644. doi: 10.1021/acs.jmedchem.2c00921. Epub 2022 Oct 17.
J Med Chem. 2022.
PMID: 36251573
Free PMC article.
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Trans-selective rhodium catalysed conjugate addition of organoboron reagents to dihydropyranones.
Edwards HJ, Goggins S, Frost CG.
Edwards HJ, et al.
Molecules. 2015 Apr 8;20(4):6153-66. doi: 10.3390/molecules20046153.
Molecules. 2015.
PMID: 25856064
Free PMC article.
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Synthetic applications of rhodium catalysed conjugate addition.
Edwards HJ, Hargrave JD, Penrose SD, Frost CG.
Edwards HJ, et al.
Chem Soc Rev. 2010 Jun;39(6):2093-105. doi: 10.1039/b919762c. Epub 2010 Apr 21.
Chem Soc Rev. 2010.
PMID: 20407730
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